Utility of green chemistry for sustainable fluorescence derivatization approach for spectrofluorimetric quantification of Darolutamide as antineoplastic drug in pharmaceutical formulation and spiked human plasma

Darolutamide is an oral nonsteroidal androgen receptor antagonist used to delay the process of prostate cancer to metastatic disease and to increase the quality of life for people with advanced prostate cancer. Here, a second spectrofluorimetric method was advanced for quantifying Darolutamide in ph...

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Veröffentlicht in:Luminescence (Chichester, England) England), 2024-03, Vol.39 (3), p.e4704-n/a
Hauptverfasser: Salem, Hesham, Abdelmajed, Mahmoud A., Rabiey, Mahmoud, Saied, Omar, Amir, Michael, Abdelgalil, Mahmoud
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container_issue 3
container_start_page e4704
container_title Luminescence (Chichester, England)
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creator Salem, Hesham
Abdelmajed, Mahmoud A.
Rabiey, Mahmoud
Saied, Omar
Amir, Michael
Abdelgalil, Mahmoud
description Darolutamide is an oral nonsteroidal androgen receptor antagonist used to delay the process of prostate cancer to metastatic disease and to increase the quality of life for people with advanced prostate cancer. Here, a second spectrofluorimetric method was advanced for quantifying Darolutamide in pharmaceutical formulation and spiked human plasma. This method depends on the fluorescence derivatization of Darolutamide with 4‐chloro‐7‐nitrobenzo‐2‐oxa‐1,3‐diazole (NBD‐Cl) at 75°C in a (pH 9) of borate buffer to produce a fluorescent derivative that can be detected at 520 nm after excitation at 460 nm. The method has been validated using ICH criteria, and it demonstrated linearity in the range 5–200 ng ml−1. The limit of detection (LOD) and limit of quantitation (LOQ) were 1.15 and 3.84 nm, respectively. The proposed method was applied precisely and accurately for quantifying Darolutamide within the pharmaceutical formulation and spiking human plasma without any interferences. Moreover, the method's sustainability was evaluated and compared with the published method using two greenness assessment tools termed analytical eco‐scale and Analytical GREEnness (AGREE). These findings suggest that the method is more sustainable than the published method. Darolutamide is an oral nonsteroidal androgen used to delay the process of prostate cancer. A spectrofluorometric method was advanced for quantifying Darolutamide in pharmaceutical formulation and spiked human plasma. The method depends on the fluorescence derivatization of Darolutamide with NBD‐Cl.
doi_str_mv 10.1002/bio.4704
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Here, a second spectrofluorimetric method was advanced for quantifying Darolutamide in pharmaceutical formulation and spiked human plasma. This method depends on the fluorescence derivatization of Darolutamide with 4‐chloro‐7‐nitrobenzo‐2‐oxa‐1,3‐diazole (NBD‐Cl) at 75°C in a (pH 9) of borate buffer to produce a fluorescent derivative that can be detected at 520 nm after excitation at 460 nm. The method has been validated using ICH criteria, and it demonstrated linearity in the range 5–200 ng ml−1. The limit of detection (LOD) and limit of quantitation (LOQ) were 1.15 and 3.84 nm, respectively. The proposed method was applied precisely and accurately for quantifying Darolutamide within the pharmaceutical formulation and spiking human plasma without any interferences. Moreover, the method's sustainability was evaluated and compared with the published method using two greenness assessment tools termed analytical eco‐scale and Analytical GREEnness (AGREE). These findings suggest that the method is more sustainable than the published method. Darolutamide is an oral nonsteroidal androgen used to delay the process of prostate cancer. A spectrofluorometric method was advanced for quantifying Darolutamide in pharmaceutical formulation and spiked human plasma. 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Here, a second spectrofluorimetric method was advanced for quantifying Darolutamide in pharmaceutical formulation and spiked human plasma. This method depends on the fluorescence derivatization of Darolutamide with 4‐chloro‐7‐nitrobenzo‐2‐oxa‐1,3‐diazole (NBD‐Cl) at 75°C in a (pH 9) of borate buffer to produce a fluorescent derivative that can be detected at 520 nm after excitation at 460 nm. The method has been validated using ICH criteria, and it demonstrated linearity in the range 5–200 ng ml−1. The limit of detection (LOD) and limit of quantitation (LOQ) were 1.15 and 3.84 nm, respectively. The proposed method was applied precisely and accurately for quantifying Darolutamide within the pharmaceutical formulation and spiking human plasma without any interferences. Moreover, the method's sustainability was evaluated and compared with the published method using two greenness assessment tools termed analytical eco‐scale and Analytical GREEnness (AGREE). These findings suggest that the method is more sustainable than the published method. Darolutamide is an oral nonsteroidal androgen used to delay the process of prostate cancer. A spectrofluorometric method was advanced for quantifying Darolutamide in pharmaceutical formulation and spiked human plasma. The method depends on the fluorescence derivatization of Darolutamide with NBD‐Cl.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38433336</pmid><doi>10.1002/bio.4704</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6467-849X</orcidid></addata></record>
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subjects 4-Chloro-7-nitrobenzofurazan
Androgen receptors
Antineoplastic Agents
Blood plasma
Buffers (chemistry)
Cancer
Darolutamide
Drug Compounding
Fluorescence
fluorescence derivatization
Green chemistry
green spectrofluorimetric method
Humans
Male
Metastases
NBD‐Cl
Pharmaceuticals
Prostate cancer
Prostatic Neoplasms
Pyrazoles
Quality of Life
Spectrofluorimetry
Spectrometry, Fluorescence
Sustainability
title Utility of green chemistry for sustainable fluorescence derivatization approach for spectrofluorimetric quantification of Darolutamide as antineoplastic drug in pharmaceutical formulation and spiked human plasma
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