L-Phenylacetylcarbinol (L-PAC): biosynthesis and industrial applications

L-Phenylacetylcarbinol (L-PAC), an important drug intermediate, can be produced by biotransformation of benzaldehyde, mainly by yeast cultures but also by Zymomonas mobilis. The biotransformation by free cells, immobilized cells, mutant organisms, purified pyruvate decarboxylase as well as the use o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:World journal of microbiology & biotechnology 2000-01, Vol.16 (6), p.499-506
Hauptverfasser: SHUKLA, V. B, KULKARNI, P. R
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 506
container_issue 6
container_start_page 499
container_title World journal of microbiology & biotechnology
container_volume 16
creator SHUKLA, V. B
KULKARNI, P. R
description L-Phenylacetylcarbinol (L-PAC), an important drug intermediate, can be produced by biotransformation of benzaldehyde, mainly by yeast cultures but also by Zymomonas mobilis. The biotransformation by free cells, immobilized cells, mutant organisms, purified pyruvate decarboxylase as well as the use of bioreactors, the downstream processing of L-PAC and the industrial applications have been reviewed.
doi_str_mv 10.1023/A:1008903817990
format Article
fullrecord <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_proquest_miscellaneous_29348877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17845189</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-a9455ad9e235be71e33ef01e75237a802544878806ac83723a564fb142b5d8173</originalsourceid><addsrcrecordid>eNqFz8FLwzAUBvAgCs7p2WtRED1Uk7ykSXYbQ50w0IOey2uasowsrU136H9vwZ28ePrg48fjfYRcM_rIKIen5YJRqg0FzZQx9ITMmFSQU6P4KZlRI00OxsA5uUhpR-mEDczIepN_bF0cA1o3jMFiX_nYhux-6perh0VW-TaNcdi65FOGsc58rA9p6D2GDLsueIuDb2O6JGcNhuSujjknXy_Pn6t1vnl_fVstN7kFVgw5GiEl1sZxkJVTzAG4hjKnJAeFmnIphFZa0wKtBsUBZSGaigleyXpaBnNy93u369vvg0tDuffJuhAwuvaQSm5AaK3-h0xpIZk2E7z5A3ftoY_TiHL6yqhCKjah2yPCZDE0PUbrU9n1fo_9WGohRKHgB_V2c4U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>752976571</pqid></control><display><type>article</type><title>L-Phenylacetylcarbinol (L-PAC): biosynthesis and industrial applications</title><source>Springer Nature - Complete Springer Journals</source><creator>SHUKLA, V. B ; KULKARNI, P. R</creator><creatorcontrib>SHUKLA, V. B ; KULKARNI, P. R</creatorcontrib><description>L-Phenylacetylcarbinol (L-PAC), an important drug intermediate, can be produced by biotransformation of benzaldehyde, mainly by yeast cultures but also by Zymomonas mobilis. The biotransformation by free cells, immobilized cells, mutant organisms, purified pyruvate decarboxylase as well as the use of bioreactors, the downstream processing of L-PAC and the industrial applications have been reviewed.</description><identifier>ISSN: 0959-3993</identifier><identifier>EISSN: 1573-0972</identifier><identifier>DOI: 10.1023/A:1008903817990</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>benzaldehyde ; Biological and medical sciences ; Bioreactors ; Biosynthesis ; Biotechnology ; Biotransformation ; Fundamental and applied biological sciences. Psychology ; Health. Pharmaceutical industry ; Industrial applications and implications. Economical aspects ; L-phenylacetylcarbinol ; Other active biomolecules ; Production of active biomolecules ; Studies ; Yeasts ; Zymomonas mobilis</subject><ispartof>World journal of microbiology &amp; biotechnology, 2000-01, Vol.16 (6), p.499-506</ispartof><rights>2001 INIST-CNRS</rights><rights>Kluwer Academic Publishers 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-a9455ad9e235be71e33ef01e75237a802544878806ac83723a564fb142b5d8173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=844467$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>SHUKLA, V. B</creatorcontrib><creatorcontrib>KULKARNI, P. R</creatorcontrib><title>L-Phenylacetylcarbinol (L-PAC): biosynthesis and industrial applications</title><title>World journal of microbiology &amp; biotechnology</title><description>L-Phenylacetylcarbinol (L-PAC), an important drug intermediate, can be produced by biotransformation of benzaldehyde, mainly by yeast cultures but also by Zymomonas mobilis. The biotransformation by free cells, immobilized cells, mutant organisms, purified pyruvate decarboxylase as well as the use of bioreactors, the downstream processing of L-PAC and the industrial applications have been reviewed.</description><subject>benzaldehyde</subject><subject>Biological and medical sciences</subject><subject>Bioreactors</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Biotransformation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health. Pharmaceutical industry</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>L-phenylacetylcarbinol</subject><subject>Other active biomolecules</subject><subject>Production of active biomolecules</subject><subject>Studies</subject><subject>Yeasts</subject><subject>Zymomonas mobilis</subject><issn>0959-3993</issn><issn>1573-0972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFz8FLwzAUBvAgCs7p2WtRED1Uk7ykSXYbQ50w0IOey2uasowsrU136H9vwZ28ePrg48fjfYRcM_rIKIen5YJRqg0FzZQx9ITMmFSQU6P4KZlRI00OxsA5uUhpR-mEDczIepN_bF0cA1o3jMFiX_nYhux-6perh0VW-TaNcdi65FOGsc58rA9p6D2GDLsueIuDb2O6JGcNhuSujjknXy_Pn6t1vnl_fVstN7kFVgw5GiEl1sZxkJVTzAG4hjKnJAeFmnIphFZa0wKtBsUBZSGaigleyXpaBnNy93u369vvg0tDuffJuhAwuvaQSm5AaK3-h0xpIZk2E7z5A3ftoY_TiHL6yqhCKjah2yPCZDE0PUbrU9n1fo_9WGohRKHgB_V2c4U</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>SHUKLA, V. B</creator><creator>KULKARNI, P. R</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TB</scope><scope>7TK</scope><scope>7U5</scope><scope>7U9</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>L7M</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope></search><sort><creationdate>20000101</creationdate><title>L-Phenylacetylcarbinol (L-PAC): biosynthesis and industrial applications</title><author>SHUKLA, V. B ; KULKARNI, P. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-a9455ad9e235be71e33ef01e75237a802544878806ac83723a564fb142b5d8173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>benzaldehyde</topic><topic>Biological and medical sciences</topic><topic>Bioreactors</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>Biotransformation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health. Pharmaceutical industry</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>L-phenylacetylcarbinol</topic><topic>Other active biomolecules</topic><topic>Production of active biomolecules</topic><topic>Studies</topic><topic>Yeasts</topic><topic>Zymomonas mobilis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHUKLA, V. B</creatorcontrib><creatorcontrib>KULKARNI, P. R</creatorcontrib><collection>Pascal-Francis</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>ABI/INFORM Global</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>World journal of microbiology &amp; biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHUKLA, V. B</au><au>KULKARNI, P. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>L-Phenylacetylcarbinol (L-PAC): biosynthesis and industrial applications</atitle><jtitle>World journal of microbiology &amp; biotechnology</jtitle><date>2000-01-01</date><risdate>2000</risdate><volume>16</volume><issue>6</issue><spage>499</spage><epage>506</epage><pages>499-506</pages><issn>0959-3993</issn><eissn>1573-0972</eissn><abstract>L-Phenylacetylcarbinol (L-PAC), an important drug intermediate, can be produced by biotransformation of benzaldehyde, mainly by yeast cultures but also by Zymomonas mobilis. The biotransformation by free cells, immobilized cells, mutant organisms, purified pyruvate decarboxylase as well as the use of bioreactors, the downstream processing of L-PAC and the industrial applications have been reviewed.</abstract><cop>Dordrecht</cop><pub>Springer</pub><doi>10.1023/A:1008903817990</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0959-3993
ispartof World journal of microbiology & biotechnology, 2000-01, Vol.16 (6), p.499-506
issn 0959-3993
1573-0972
language eng
recordid cdi_proquest_miscellaneous_29348877
source Springer Nature - Complete Springer Journals
subjects benzaldehyde
Biological and medical sciences
Bioreactors
Biosynthesis
Biotechnology
Biotransformation
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
L-phenylacetylcarbinol
Other active biomolecules
Production of active biomolecules
Studies
Yeasts
Zymomonas mobilis
title L-Phenylacetylcarbinol (L-PAC): biosynthesis and industrial applications
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T06%3A55%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=L-Phenylacetylcarbinol%20(L-PAC):%20biosynthesis%20and%20industrial%20applications&rft.jtitle=World%20journal%20of%20microbiology%20&%20biotechnology&rft.au=SHUKLA,%20V.%20B&rft.date=2000-01-01&rft.volume=16&rft.issue=6&rft.spage=499&rft.epage=506&rft.pages=499-506&rft.issn=0959-3993&rft.eissn=1573-0972&rft_id=info:doi/10.1023/A:1008903817990&rft_dat=%3Cproquest_pasca%3E17845189%3C/proquest_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=752976571&rft_id=info:pmid/&rfr_iscdi=true