L-Phenylacetylcarbinol (L-PAC): biosynthesis and industrial applications

L-Phenylacetylcarbinol (L-PAC), an important drug intermediate, can be produced by biotransformation of benzaldehyde, mainly by yeast cultures but also by Zymomonas mobilis. The biotransformation by free cells, immobilized cells, mutant organisms, purified pyruvate decarboxylase as well as the use o...

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Veröffentlicht in:	World journal of microbiology & biotechnology 2000-01, Vol.16 (6), p.499-506
Hauptverfasser:	SHUKLA, V. B, KULKARNI, P. R
Format:	Artikel
Sprache:	eng
Schlagworte:	benzaldehyde Biological and medical sciences Bioreactors Biosynthesis Biotechnology Biotransformation Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects L-phenylacetylcarbinol Other active biomolecules Production of active biomolecules Studies Yeasts Zymomonas mobilis
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Beschreibung
Zusammenfassung:	L-Phenylacetylcarbinol (L-PAC), an important drug intermediate, can be produced by biotransformation of benzaldehyde, mainly by yeast cultures but also by Zymomonas mobilis. The biotransformation by free cells, immobilized cells, mutant organisms, purified pyruvate decarboxylase as well as the use of bioreactors, the downstream processing of L-PAC and the industrial applications have been reviewed.
ISSN:	0959-3993 1573-0972
DOI:	10.1023/A:1008903817990