Telencephalic eversion in embryos and early larvae of four teleost species
The telencephalon of ray‐finned fishes undergoes eversion, which is very different to the evagination that occurs in most other vertebrates. Ventricle morphogenesis is key to build an everted telencephalon. Thus, here we use the apical marker zona occludens 1 to understand ventricle morphology, exte...
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Veröffentlicht in: | Evolution & development 2024-03, Vol.26 (2), p.e12474-n/a |
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Zusammenfassung: | The telencephalon of ray‐finned fishes undergoes eversion, which is very different to the evagination that occurs in most other vertebrates. Ventricle morphogenesis is key to build an everted telencephalon. Thus, here we use the apical marker zona occludens 1 to understand ventricle morphology, extension of the tela choroidea and the eversion process during early telencephalon development of four teleost species: giant danio (Devario aequipinnatus), blind cavefish (Astyanax mexicanus), medaka (Oryzias latipes), and paradise fish (Macroposus opercularis). In addition, by using immunohistochemistry against tubulin and calcium‐binding proteins, we analyze the general morphology of the telencephalon, showing changes in the location and extension of the olfactory bulb and other telencephalic regions from 2 to 5 days of development. We also analyze the impact of abnormal eye and telencephalon morphogenesis on eversion, showing that cyclops mutants do undergo eversion despite very dramatic abnormal eye morphology. We discuss how the formation of the telencephalic ventricle in teleost fish, with its characteristic shape, is a crucial event during eversion.
The telencephalon of ray‐finned fishes undergoes eversion, not evagination as in the rest of vertebrates. We show that the formation of the ventricle followed by a rostro‐caudal telencephalic expansion is key for the formation of an everted telencephalon in teleosts.
Research highlights
The developmental events that lead to an everted telencephalon in ray‐finned fishes are not well understood. Here we show that the morphology of the telencephalic ventricle is quite similar between five species of teleosts, being a key event during eversion. We also show the transformation that the telencephalon undergoes from 2 to 4/5 days of development, including growth that leads to an expansion along the rostro‐caudal axis and that results in a fully everted telencephalon. Our results support the idea that these two key events, ventricle formation and telencephalon elongation, are at the core of the formation of an everted telencephalon in teleosts. In addition, we show zebrafish cyclops mutants develop an everted telencephalon despite very abnormal neurulation that alters ventricle and eye morphology. Our results provide experimental basis for the only model of eversion based in development data. |
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ISSN: | 1520-541X 1525-142X |
DOI: | 10.1111/ede.12474 |