Sequence Analysis of Six Candidate Genes in Miniature Schnauzers with Primary Hypertriglyceridemia

Miniature Schnauzers are predisposed to primary hypertriglyceridemia (HTG). In this study, we performed whole genome sequencing (WGS) of eight Miniature Schnauzers with primary HTG and screened for risk variants in six HTG candidate genes: , , , , , and . Variants were filtered to identify those pre...

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Veröffentlicht in:	Genes 2024-01, Vol.15 (2), p.193
Hauptverfasser:	Tate, Nicole M, Underwood, Michaela, Thomas-Hollands, Alison, Minor, Katie M, Cullen, Jonah N, Friedenberg, Steven G, Mickelson, James R, Xenoulis, Panagiotis G, Steiner, Joerg M, Furrow, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Diabetes DNA sequencing Dogs Enzymes Ethylenediaminetetraacetic acid Gene frequency Genes Genomes Genomics Genotype Genotype & phenotype Genotypes Humans Hyperlipidemia Hypertriglyceridemia Hypertriglyceridemia - genetics Hypertriglyceridemia - veterinary Hypothyroidism Lipids Metabolism Nucleotide sequencing Sequence Analysis Single-nucleotide polymorphism Tata box Triglycerides Triglycerides - genetics Whole genome sequencing
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Zusammenfassung:	Miniature Schnauzers are predisposed to primary hypertriglyceridemia (HTG). In this study, we performed whole genome sequencing (WGS) of eight Miniature Schnauzers with primary HTG and screened for risk variants in six HTG candidate genes: , , , , , and . Variants were filtered to identify those present in ≥2 Miniature Schnauzers with primary HTG and uncommon (
ISSN:	2073-4425 2073-4425
DOI:	10.3390/genes15020193