Electrically Controlled Drug Delivery from Biotin-Doped Conductive Polypyrrole

Electrically Controlled Drug Delivery from Biotin-Doped Conductive Polypyrrole

A platform for controlled drug delivery using a conductive‐polymer substrate has been created. Through the incorporation of biotin into the conductive polymer polypyrrole (PPy) and the subsequent attachment of the desired drug molecule (such as nerve growth factor, NGF) via a streptavidin linker, an...

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Veröffentlicht in:Advanced materials (Weinheim) 2006-03, Vol.18 (5), p.577-581
Hauptverfasser: George, P. M., LaVan, D. A., Burdick, J. A., Chen, C.-Y., Liang, E., Langer, R.
Format: Artikel
Sprache:eng
Schlagworte:
Biomolecules
Cells
Drug delivery
Electroactive materials
Polymeric materials
Polypyrroles
Stimuli-responsive materials
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Zusammenfassung:A platform for controlled drug delivery using a conductive‐polymer substrate has been created. Through the incorporation of biotin into the conductive polymer polypyrrole (PPy) and the subsequent attachment of the desired drug molecule (such as nerve growth factor, NGF) via a streptavidin linker, an applied potential can trigger release of the drug from the polymer surface (see figure).
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200501242