Expert recommendations for the management of iron deficiency in patients with heart failure in Asia

Iron deficiency is a common comorbidity in heart failure (HF) and is independently associated with a worse quality-of-life and exercise capacity, as well as increased risk of hospitalization, regardless of anemia status. Although international guidelines have provided recommendations for the management of iron deficiency in patients with HF, guidelines in Asia are less established, and practical use of guidelines for management of iron deficiency is limited in the region. A panel comprising cardiologists from China, Hong Kong, India, Japan, Malaysia, Pakistan, Philippines, Singapore, South Korea, Taiwan, and Thailand convened to share insights and provide guidance for the optimal management of iron deficiency in patients with HF, tailored for the Asian community. Expert opinions were provided for the screening, diagnosis, treatment and monitoring of iron deficiency in patients with HF. It was recommended that all patients with HF with reduced ejection fraction should be screened for iron deficiency, and iron-deficient patients should be treated with intravenous iron. Monitoring of iron levels in patients with HF should be carried out once or twice yearly. Barriers to the management of iron deficiency in patients with HF in the region include low awareness of iron deficiency amongst general physicians, lack of reimbursement for screening and treatment, and lack of proper facilities for administration of intravenous iron. These recommendations provide a structured approach to the management of iron deficiency in patients with HF in Asia. •Iron deficiency in heart failure results in worse outcomes regardless of anemia.•Expert opinions on the optimal management of iron deficiency in Asia are provided.•All patients with heart failure should be screened for iron deficiency.•Preferred treatment is intravenous iron; oral iron was ineffective in clinical trials.•Challenges in Asia include low awareness, cost, and lack of facilities.