Neurons in the hypothalamus counteract ageing in mice

In mice, a subset of neurons in the dorsomedial hypothalamus control sympathetic nervous system signalling to adipose tissue and are dysregulated with age; activating these neurons prolongs lifespan and slows the decline in physical activity associated with ageing.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews. Neuroscience 2024-03, Vol.25 (3), p.141-141
1. Verfasser:	Willson, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1488/1562 631/378/2611 631/378/3920 631/443/7 Adipose tissue Aging Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Body fat Exercise Gene expression Hypothalamus Hypothalamus (dorsomedial) Kinases Life span Localization Neurobiology Neurons Neuropeptides Neurosciences Physical activity Research Highlight Respiration Sensors Sympathetic nervous system
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Beschreibung
Zusammenfassung:	In mice, a subset of neurons in the dorsomedial hypothalamus control sympathetic nervous system signalling to adipose tissue and are dysregulated with age; activating these neurons prolongs lifespan and slows the decline in physical activity associated with ageing.
ISSN:	1471-003X 1471-0048 1469-3178
DOI:	10.1038/s41583-024-00794-1