Streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis from retroperitoneal panniculitis during the treatment with anti-IL-6 receptor antibody: A case report

A 53-year-old man with adult-onset Still's disease developed severe streptococcal toxic shock syndrome (STSS) due to Streptococcus dysgalactiae subsp. equisimilis (SDSE), following retroperitoneal panniculitis. He was receiving tocilizumab (TCZ), an interleukin-6 receptor inhibitor. The modifyi...

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Veröffentlicht in:	Modern rheumatology case reports 2024-07, Vol.8 (2), p.255-258
Hauptverfasser:	Fujimoto, Sho, Eriguchi, Yoshihiro, Nakamura, Rinto, Kamikawa, Sota, Yonekawa, Akiko, Miyake, Noriko, Ono, Nobuyuki, Niiro, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Humans Male Middle Aged Panniculitis - diagnosis Panniculitis - drug therapy Panniculitis - etiology Panniculitis - microbiology Receptors, Interleukin-6 - antagonists & inhibitors Retroperitoneal Space Shock, Septic - diagnosis Shock, Septic - drug therapy Shock, Septic - etiology Shock, Septic - microbiology Still's Disease, Adult-Onset - complications Still's Disease, Adult-Onset - diagnosis Still's Disease, Adult-Onset - drug therapy Streptococcal Infections - complications Streptococcal Infections - diagnosis Streptococcal Infections - drug therapy Streptococcal Infections - microbiology Streptococcus - immunology Treatment Outcome
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Zusammenfassung:	A 53-year-old man with adult-onset Still's disease developed severe streptococcal toxic shock syndrome (STSS) due to Streptococcus dysgalactiae subsp. equisimilis (SDSE), following retroperitoneal panniculitis. He was receiving tocilizumab (TCZ), an interleukin-6 receptor inhibitor. The modifying effect of TCZ on the immune response and the pathophysiology of SDSE infection may have led to retroperitoneal panniculitis and atypical STSS with delayed shock and flare of soft tissue inflammation.
ISSN:	2472-5625 2472-5625
DOI:	10.1093/mrcr/rxae001