Changes in wider field swept-source OCT angiography vascular metrics with anti-vascular endothelial growth factor therapy in central retinal vein occlusion

Purpose To investigate the impact of anti-VEGF therapy on vascular metrics in eyes with macular edema secondary to central retinal vein occlusion (CRVO) using wider field swept-source OCT angiography (WF SS-OCTA). Methods We included 23 eyes with macular edema associated with non-ischemic CRVO from...

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Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 2024-07, Vol.262 (7), p.2111-2120
Hauptverfasser:	Razavi, Peyman, Baldwin, Grace, Garg, Itika, Velazquez, Luis Martinez, Garcia, Mauricio, Gan, Jenny, Choi, Hanna, Zeng, Rebecca, Vingopoulos, Filippos, Husain, Deeba, Kim, Leo A., Patel, Nimesh A., Miller, John B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Aged Aged, 80 and over Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - therapeutic use Angiography Bevacizumab - administration & dosage Bevacizumab - therapeutic use Edema Female Fluorescein Angiography - methods Follow-Up Studies Fundus Oculi Humans Intravitreal Injections Ischemia Macular Edema - diagnosis Macular Edema - drug therapy Macular Edema - etiology Macular Edema - physiopathology Male Medical imaging Medicine Medicine & Public Health Microvasculature Middle Aged Occlusion Ophthalmology Ranibizumab - administration & dosage Receptors, Vascular Endothelial Growth Factor - administration & dosage Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Receptors, Vascular Endothelial Growth Factor - therapeutic use Retina Retinal Disorders Retinal Vein Occlusion - diagnosis Retinal Vein Occlusion - drug therapy Retinal Vein Occlusion - physiopathology Retinal Vessels - diagnostic imaging Retinal Vessels - pathology Retrospective Studies Tomography, Optical Coherence - methods Treatment Outcome Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Visual Acuity
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Zusammenfassung:	Purpose To investigate the impact of anti-VEGF therapy on vascular metrics in eyes with macular edema secondary to central retinal vein occlusion (CRVO) using wider field swept-source OCT angiography (WF SS-OCTA). Methods We included 23 eyes with macular edema associated with non-ischemic CRVO from 22 patients treated with anti-VEGF therapy (median number of injections: 5 [2–9]). Changes in vessel density (VD), vessel skeletonized density (VSD), and foveal avascular zone (FAZ) parameters were measured using WF SS-OCTA. Visual acuity (VA) and central subfield thickness (CST) were also measured. Results Median CST decreased significantly from 369 µm (305–531) to 267 µm (243–300, p
ISSN:	0721-832X 1435-702X 1435-702X
DOI:	10.1007/s00417-024-06410-3