Associations of sleep-related variables with reverse dipping patterns of blood pressure in α-synucleinopathies
The reverse dipping blood pressure (BP) pattern is very common in α-synucleinopathies. We aimed to explore the associations of sleep-related variables with abnormal BP circadian rhythms in Parkinson's disease (PD) and multiple system atrophy (MSA). A total of 126 patients, 76 with PD and 50 wit...
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| Veröffentlicht in: | Parkinsonism & related disorders 2024-04, Vol.121, p.106046-106046, Article 106046 |
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| container_title | Parkinsonism & related disorders |
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| creator | Sun, Yunchuang Wei, Luhua Li, Fan Ling, Chen Zhai, Fei Lv, Yunfeng Zhou, Hong Zhang, Cheng Ma, Jing Chen, Jing Sun, Wei Wang, Zhaoxia |
| description | The reverse dipping blood pressure (BP) pattern is very common in α-synucleinopathies. We aimed to explore the associations of sleep-related variables with abnormal BP circadian rhythms in Parkinson's disease (PD) and multiple system atrophy (MSA).
A total of 126 patients, 76 with PD and 50 with MSA, were included. All participants underwent ambulatory BP monitoring and full-night polysomnography (PSG). We analyzed abnormal dipping patterns and sleep-related parameters, including moderate to severe obstructive sleep apnea (OSA), rapid eye movement behavior disorder (RBD), average oxygen saturation (SaO2%), lowest SaO2%, duration of SaO2% |
| doi_str_mv | 10.1016/j.parkreldis.2024.106046 |
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A total of 126 patients, 76 with PD and 50 with MSA, were included. All participants underwent ambulatory BP monitoring and full-night polysomnography (PSG). We analyzed abnormal dipping patterns and sleep-related parameters, including moderate to severe obstructive sleep apnea (OSA), rapid eye movement behavior disorder (RBD), average oxygen saturation (SaO2%), lowest SaO2%, duration of SaO2% <90%, and apnea-hypopnea index (AHI). Binary logistic regression was performed to explore the associations between paraclinical variables, sleep-related variables, and reverse dipping patterns.
Reverse dipping patterns were predominant in patients with PD (58.5 %) and MSA (68.0 %). Patients with MSA had higher AHI, RBD, and lower average SaO2% than those with PD. Taking both diseases together as a whole group of α-synucleinopathies, logistic regression analysis indicates the Hoehn-Yahr stage (odds ratio [OR] = 2.00 for reverse systolic and 2.34 for reverse diastolic dipping patterns), moderate to severe OSA (OR = 2.71 for reverse systolic and 2.53 for reverse diastolic dipping patterns), average SaO2% (OR = 1.35 for reverse systolic dipping patterns), and male sex (OR = 2.70 for reverse diastolic dipping patterns) were independently associated with reverse dipping patterns.
Reverse dipping patterns were common in patients with PD and MSA. Hoehn-Yahr stage, moderate to severe OSA, average SaO2%, and male sex were associated with reverse dipping patterns in α-synucleinopathy.
•Both MSA and PD are accompanied by higher proportions of reverse dipping patterns of BP and sleep related disorders.•Reverse dipping pattern was associated with Hoehn-Yahr stage, male sex, average oxygen saturation and moderate to severe OSA.•In PD and MSA, interactions between sleep-related disorders and BP profiles might present a potential intervention target.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/j.parkreldis.2024.106046</identifier><identifier>PMID: 38367532</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Ambulatory blood pressure monitoring ; Circadian rhythms ; Multiple system atrophy ; Parkinson's disease ; Sleep abnormality</subject><ispartof>Parkinsonism & related disorders, 2024-04, Vol.121, p.106046-106046, Article 106046</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c319t-285231425ad6aecda1fd541abc05f337cfda74342f15fefa10a46db51426547c3</cites><orcidid>0000-0003-3056-1573 ; 0000-0001-5123-936X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.parkreldis.2024.106046$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38367532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Yunchuang</creatorcontrib><creatorcontrib>Wei, Luhua</creatorcontrib><creatorcontrib>Li, Fan</creatorcontrib><creatorcontrib>Ling, Chen</creatorcontrib><creatorcontrib>Zhai, Fei</creatorcontrib><creatorcontrib>Lv, Yunfeng</creatorcontrib><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Zhang, Cheng</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Sun, Wei</creatorcontrib><creatorcontrib>Wang, Zhaoxia</creatorcontrib><title>Associations of sleep-related variables with reverse dipping patterns of blood pressure in α-synucleinopathies</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>The reverse dipping blood pressure (BP) pattern is very common in α-synucleinopathies. We aimed to explore the associations of sleep-related variables with abnormal BP circadian rhythms in Parkinson's disease (PD) and multiple system atrophy (MSA).
A total of 126 patients, 76 with PD and 50 with MSA, were included. All participants underwent ambulatory BP monitoring and full-night polysomnography (PSG). We analyzed abnormal dipping patterns and sleep-related parameters, including moderate to severe obstructive sleep apnea (OSA), rapid eye movement behavior disorder (RBD), average oxygen saturation (SaO2%), lowest SaO2%, duration of SaO2% <90%, and apnea-hypopnea index (AHI). Binary logistic regression was performed to explore the associations between paraclinical variables, sleep-related variables, and reverse dipping patterns.
Reverse dipping patterns were predominant in patients with PD (58.5 %) and MSA (68.0 %). Patients with MSA had higher AHI, RBD, and lower average SaO2% than those with PD. Taking both diseases together as a whole group of α-synucleinopathies, logistic regression analysis indicates the Hoehn-Yahr stage (odds ratio [OR] = 2.00 for reverse systolic and 2.34 for reverse diastolic dipping patterns), moderate to severe OSA (OR = 2.71 for reverse systolic and 2.53 for reverse diastolic dipping patterns), average SaO2% (OR = 1.35 for reverse systolic dipping patterns), and male sex (OR = 2.70 for reverse diastolic dipping patterns) were independently associated with reverse dipping patterns.
Reverse dipping patterns were common in patients with PD and MSA. Hoehn-Yahr stage, moderate to severe OSA, average SaO2%, and male sex were associated with reverse dipping patterns in α-synucleinopathy.
•Both MSA and PD are accompanied by higher proportions of reverse dipping patterns of BP and sleep related disorders.•Reverse dipping pattern was associated with Hoehn-Yahr stage, male sex, average oxygen saturation and moderate to severe OSA.•In PD and MSA, interactions between sleep-related disorders and BP profiles might present a potential intervention target.</description><subject>Ambulatory blood pressure monitoring</subject><subject>Circadian rhythms</subject><subject>Multiple system atrophy</subject><subject>Parkinson's disease</subject><subject>Sleep abnormality</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkM1O3DAQx62KqnyUV6h85JKtP2InewQEbaWVeoGz5dhj8DYbp55kEY_VF-kzYZQtHHua0ej3n9H8CKGcrTjj-ut2Ndr8K0PvI64EE3UZa1brD-SEt42sFBf6qPRSyaplgh2TU8QtY6xRTH4ix7KVulFSnJB0iZhctFNMA9IUKPYAY1VW2wk83dscbdcD0qc4PdIMe8gI1MdxjMMDHe00QV6CXZ-Sp2MGxDkDjQP9-6fC52F2PcQhFfQxAn4mH4PtEc4P9Yzc397cXX-vNj-__bi-3FRO8vVUiVYJyWuhrNcWnLc8eFVz2zmmgpSNC942taxF4CpAsJzZWvtOlYhWdePkGblY9o45_Z4BJ7OL6KDv7QBpRiPWohWKabEuaLugLifEDMGMOe5sfjacmVfdZmvedZtX3WbRXaJfDlfmbgf-LfjPbwGuFgDKr_sI2aCLMDjwMYObjE_x_1deAPbimbs</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Sun, Yunchuang</creator><creator>Wei, Luhua</creator><creator>Li, Fan</creator><creator>Ling, Chen</creator><creator>Zhai, Fei</creator><creator>Lv, Yunfeng</creator><creator>Zhou, Hong</creator><creator>Zhang, Cheng</creator><creator>Ma, Jing</creator><creator>Chen, Jing</creator><creator>Sun, Wei</creator><creator>Wang, Zhaoxia</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3056-1573</orcidid><orcidid>https://orcid.org/0000-0001-5123-936X</orcidid></search><sort><creationdate>20240401</creationdate><title>Associations of sleep-related variables with reverse dipping patterns of blood pressure in α-synucleinopathies</title><author>Sun, Yunchuang ; Wei, Luhua ; Li, Fan ; Ling, Chen ; Zhai, Fei ; Lv, Yunfeng ; Zhou, Hong ; Zhang, Cheng ; Ma, Jing ; Chen, Jing ; Sun, Wei ; Wang, Zhaoxia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-285231425ad6aecda1fd541abc05f337cfda74342f15fefa10a46db51426547c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ambulatory blood pressure monitoring</topic><topic>Circadian rhythms</topic><topic>Multiple system atrophy</topic><topic>Parkinson's disease</topic><topic>Sleep abnormality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Yunchuang</creatorcontrib><creatorcontrib>Wei, Luhua</creatorcontrib><creatorcontrib>Li, Fan</creatorcontrib><creatorcontrib>Ling, Chen</creatorcontrib><creatorcontrib>Zhai, Fei</creatorcontrib><creatorcontrib>Lv, Yunfeng</creatorcontrib><creatorcontrib>Zhou, Hong</creatorcontrib><creatorcontrib>Zhang, Cheng</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Chen, Jing</creatorcontrib><creatorcontrib>Sun, Wei</creatorcontrib><creatorcontrib>Wang, Zhaoxia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Yunchuang</au><au>Wei, Luhua</au><au>Li, Fan</au><au>Ling, Chen</au><au>Zhai, Fei</au><au>Lv, Yunfeng</au><au>Zhou, Hong</au><au>Zhang, Cheng</au><au>Ma, Jing</au><au>Chen, Jing</au><au>Sun, Wei</au><au>Wang, Zhaoxia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of sleep-related variables with reverse dipping patterns of blood pressure in α-synucleinopathies</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>121</volume><spage>106046</spage><epage>106046</epage><pages>106046-106046</pages><artnum>106046</artnum><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>The reverse dipping blood pressure (BP) pattern is very common in α-synucleinopathies. We aimed to explore the associations of sleep-related variables with abnormal BP circadian rhythms in Parkinson's disease (PD) and multiple system atrophy (MSA).
A total of 126 patients, 76 with PD and 50 with MSA, were included. All participants underwent ambulatory BP monitoring and full-night polysomnography (PSG). We analyzed abnormal dipping patterns and sleep-related parameters, including moderate to severe obstructive sleep apnea (OSA), rapid eye movement behavior disorder (RBD), average oxygen saturation (SaO2%), lowest SaO2%, duration of SaO2% <90%, and apnea-hypopnea index (AHI). Binary logistic regression was performed to explore the associations between paraclinical variables, sleep-related variables, and reverse dipping patterns.
Reverse dipping patterns were predominant in patients with PD (58.5 %) and MSA (68.0 %). Patients with MSA had higher AHI, RBD, and lower average SaO2% than those with PD. Taking both diseases together as a whole group of α-synucleinopathies, logistic regression analysis indicates the Hoehn-Yahr stage (odds ratio [OR] = 2.00 for reverse systolic and 2.34 for reverse diastolic dipping patterns), moderate to severe OSA (OR = 2.71 for reverse systolic and 2.53 for reverse diastolic dipping patterns), average SaO2% (OR = 1.35 for reverse systolic dipping patterns), and male sex (OR = 2.70 for reverse diastolic dipping patterns) were independently associated with reverse dipping patterns.
Reverse dipping patterns were common in patients with PD and MSA. Hoehn-Yahr stage, moderate to severe OSA, average SaO2%, and male sex were associated with reverse dipping patterns in α-synucleinopathy.
•Both MSA and PD are accompanied by higher proportions of reverse dipping patterns of BP and sleep related disorders.•Reverse dipping pattern was associated with Hoehn-Yahr stage, male sex, average oxygen saturation and moderate to severe OSA.•In PD and MSA, interactions between sleep-related disorders and BP profiles might present a potential intervention target.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38367532</pmid><doi>10.1016/j.parkreldis.2024.106046</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3056-1573</orcidid><orcidid>https://orcid.org/0000-0001-5123-936X</orcidid></addata></record> |
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| subjects | Ambulatory blood pressure monitoring Circadian rhythms Multiple system atrophy Parkinson's disease Sleep abnormality |
| title | Associations of sleep-related variables with reverse dipping patterns of blood pressure in α-synucleinopathies |
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