Donor fat‐to‐muscle ratio and kidney transplant outcomes: A proposition of metabolic memory

Aims The impact of donor abdominal fat‐to‐muscle ratio (FMR) on kidney transplant (KT) outcomes was assessed. Given the transient nature of the donor's metabolic environment in transplant recipients, this study investigated the capacity of body composition to induce metabolic memory effects. Materials and Methods KT patients (n = 895) who received allografts from living donors (2003–2013) were included. Donor fat and muscle were quantified using pre‐KT abdominal computed tomography scans. Patients were categorised into donor FMR tertiles and followed up for graft outcomes. Additionally, genome‐wide DNA methylation analysis was performed on 28 kidney graft samples from KT patients in the low‐ and high‐FMR groups. Results Mean recipient age was 42.9 ± 11.4 years and 60.9% were males. Donor FMR averaged 1.67 ± 0.79. Over a median of 120.9 ± 42.5 months, graft failure (n = 127) and death‐censored graft failure (n = 109) were more frequent in the higher FMR tertiles. Adjusted hazard ratios for the highest versus lowest FMR tertile were 1.71 (95% CI, 1.06–2.75) for overall graft failure and 1.90 (95% CI, 1.13–3.20) for death‐censored graft failure. Genome‐wide DNA methylation analysis identified 58 differentially methylated regions (p 0.2) and 35 genes showed differential methylation between the high‐ (FMR >1.91) and low‐FMR (FMR