Histological evidence of hypothyroidism in mice chronically exposed to conventional farming

Worldwide, disorders of the thyroid gland are a growing concern; such can be caused by exposure to contaminants, including agrochemicals used in conventional agriculture, which act as endocrine disruptors. The purpose of this study is to evaluate whether or not exposure to an environment with conventional agriculture leads to thyroid disruption. Mus musculus were used as bioindicator species, captured in two sites: a farm where conventional agriculture is practiced, and a place without agriculture. Thyroid histomorphometric and morphologic data were analyzed. The impacts of the agricultural environment over the thyroid were revealed, as indications of hypothyroidism were observed in exposed mice: the area and volume of epithelial cells were much lower. Alterations in thyroid histomorphology were also observed: lower follicular sphericity, irregularly delimited epithelium and increased exfoliation into the colloid. These results highlight the need for transition from current conventional agricultural systems towards organic systems. •Thyroid disruption can be induced by chronic exposure to an environment in which conventional agriculture is practiced.•Chronic exposure to contaminants derived of conventional agriculture leads to histological alterations in the thyroid.•Histological alterations in the thyroid reveals loss of functionality.•The thyroid of exposed individuals is much less functional.