The role of placental insufficiency in spontaneous preterm birth: A literature review

•Placental insufficiency is emerging as a contributor to spontaneous preterm birth.•Thrombin may be involved in mechanisms leading to spontaneous preterm birth.•PAPP-A and PlGF may prove useful in the prediction in spontaneous preterm birth. Preterm Birth (delivery before 37 weeks of gestation) is the leading cause of childhood mortality and is also associated with significant morbidity both in the neonatal period and beyond. The aetiology of spontaneous preterm birth is unclear and likely multifactorial incorporating factors such as infection/inflammation and cervical injury. Placental insufficiency is emerging as an additional contributor to spontaneous preterm delivery; however, the mechanisms by which this occurs are not fully understood. Serum biomarkers and imaging techniques have been investigated as potential predictors of placental insufficiency, however none have yet been found to have a sufficient predictive value. This review examines the evidence for the role of the placenta in preterm birth, preterm prelabour rupture of the membranes and abruption as well as highlighting areas where further research is required.