Prognostic significance of bone marrow fibrosis in diffuse large B‐cell lymphoma

Introduction Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin lymphomas. The aim of this study is to determine the relationship between the increase in the degree of fibrosis in the bone marrow and prognosis and mortality in newly diagnosed DLBCL. Methods Bone marrow b...

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Veröffentlicht in:International journal of laboratory hematology 2024-06, Vol.46 (3), p.523-530
Hauptverfasser: Cetintepe, Tugba, Ozkan, Gamze, Kucukzeybek, Betul Polat, Cetintepe, Lutfi, Unal, Demet Kiper, Solmaz, Serife, Aygun, Kemal, Acar, Alev Garip, Bener, Sadi, Çallı, Aylin Orgen, Payzın, Kadriye Bahriye
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Sprache:eng
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Zusammenfassung:Introduction Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin lymphomas. The aim of this study is to determine the relationship between the increase in the degree of fibrosis in the bone marrow and prognosis and mortality in newly diagnosed DLBCL. Methods Bone marrow biopsy of 153 newly diagnosed DLBCL patients was determined by staining with reticulin, Masson's trichrome histochemical stain, and the degree of fibrosis was determined. Results In the bone marrow biopsy performed at the time of diagnosis, bone marrow fibrosis (BMF) was observed in 70 patients. While BMF‐1 was detected in 42 patients (60%), BMF‐2 was detected in 25 patients (35%) and BMF‐3 was detected in 3 patients (4%). As the degree of BMF increased, the median overall survival and median progression‐free survival times were significantly shorter (p: 0.008), (p 
ISSN:1751-5521
1751-553X
DOI:10.1111/ijlh.14249