Rheumatoid arthritis autoantibodies benefit from inflammation temperatures
Symptoms of rheumatoid arthritis are associated with local inflammation and may include low-grade fever. To establish the role of fever/inflammation temperatures (38℃-39℃) on the activity of autoantibodies and therapeutic antibodies relevant for rheumatoid arthritis. Through the use of molecular dyn...
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| Veröffentlicht in: | International immunopharmacology 2024-03, Vol.129, p.111690-111690, Article 111690 |
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| container_title | International immunopharmacology |
| container_volume | 129 |
| creator | Singh, Puneet K. Stan, Razvan C. |
| description | Symptoms of rheumatoid arthritis are associated with local inflammation and may include low-grade fever.
To establish the role of fever/inflammation temperatures (38℃-39℃) on the activity of autoantibodies and therapeutic antibodies relevant for rheumatoid arthritis.
Through the use of molecular dynamics and free energy calculations, we investigated the role of temperature on the formation of pertinent immune complexes.
Rheumatoid arthritis autoantibodies bind with higher affinity at febrile/inflammation temperatures.
Fever may modulate binding affinity of autoantibodies relevant for rheumatoid arthritis. |
| doi_str_mv | 10.1016/j.intimp.2024.111690 |
| format | Article |
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To establish the role of fever/inflammation temperatures (38℃-39℃) on the activity of autoantibodies and therapeutic antibodies relevant for rheumatoid arthritis.
Through the use of molecular dynamics and free energy calculations, we investigated the role of temperature on the formation of pertinent immune complexes.
Rheumatoid arthritis autoantibodies bind with higher affinity at febrile/inflammation temperatures.
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To establish the role of fever/inflammation temperatures (38℃-39℃) on the activity of autoantibodies and therapeutic antibodies relevant for rheumatoid arthritis.
Through the use of molecular dynamics and free energy calculations, we investigated the role of temperature on the formation of pertinent immune complexes.
Rheumatoid arthritis autoantibodies bind with higher affinity at febrile/inflammation temperatures.
Fever may modulate binding affinity of autoantibodies relevant for rheumatoid arthritis.</description><subject>Antibody therapy</subject><subject>Autoantibodies</subject><subject>Fever</subject><subject>Inflammation</subject><subject>Rheumatoid arthritis</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMojq9_INKlm465adKmG0HEJwOC6Dok7Q1maJsxSQX_vR06unR1H5xzD_cj5BzoEiiUV-ulG5LrN0tGGV8CQFnTPXIEspI5VFTsT70oq1xUZb0gxzGuKZ32HA7JopCF4ALoEXl-_cCx18m7NtMhfQSXXMz0mLyerhvfOoyZwQGtS5kNvs_cYDvdTxbnhyxhv8Gg0xgwnpIDq7uIZ7t6Qt7v795uH_PVy8PT7c0qbwqAlIPlSAstjbQMDataI6Et-TQ3lBppNJVGlBYEsIJbgyho0Va04CA4l6IuTsjlfHcT_OeIManexQa7Tg_ox6hYzSpGaya3Uj5Lm-BjDGjVJrheh28FVG0pqrWaKaotRTVTnGwXu4TR9Nj-mX6xTYLrWYDTn18Og4qNw6HB1gVskmq9-z_hB1y_hfA</recordid><startdate>20240310</startdate><enddate>20240310</enddate><creator>Singh, Puneet K.</creator><creator>Stan, Razvan C.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240310</creationdate><title>Rheumatoid arthritis autoantibodies benefit from inflammation temperatures</title><author>Singh, Puneet K. ; Stan, Razvan C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-1f4e03a8b8f2eb27db81d648b8c00b8ba08b56f151234fbee503d703415448593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antibody therapy</topic><topic>Autoantibodies</topic><topic>Fever</topic><topic>Inflammation</topic><topic>Rheumatoid arthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Puneet K.</creatorcontrib><creatorcontrib>Stan, Razvan C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Puneet K.</au><au>Stan, Razvan C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rheumatoid arthritis autoantibodies benefit from inflammation temperatures</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2024-03-10</date><risdate>2024</risdate><volume>129</volume><spage>111690</spage><epage>111690</epage><pages>111690-111690</pages><artnum>111690</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Symptoms of rheumatoid arthritis are associated with local inflammation and may include low-grade fever.
To establish the role of fever/inflammation temperatures (38℃-39℃) on the activity of autoantibodies and therapeutic antibodies relevant for rheumatoid arthritis.
Through the use of molecular dynamics and free energy calculations, we investigated the role of temperature on the formation of pertinent immune complexes.
Rheumatoid arthritis autoantibodies bind with higher affinity at febrile/inflammation temperatures.
Fever may modulate binding affinity of autoantibodies relevant for rheumatoid arthritis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38354510</pmid><doi>10.1016/j.intimp.2024.111690</doi><tpages>1</tpages></addata></record> |
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| ispartof | International immunopharmacology, 2024-03, Vol.129, p.111690-111690, Article 111690 |
| issn | 1567-5769 1878-1705 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Antibody therapy Autoantibodies Fever Inflammation Rheumatoid arthritis |
| title | Rheumatoid arthritis autoantibodies benefit from inflammation temperatures |
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