Rheumatoid arthritis autoantibodies benefit from inflammation temperatures

Symptoms of rheumatoid arthritis are associated with local inflammation and may include low-grade fever. To establish the role of fever/inflammation temperatures (38℃-39℃) on the activity of autoantibodies and therapeutic antibodies relevant for rheumatoid arthritis. Through the use of molecular dynamics and free energy calculations, we investigated the role of temperature on the formation of pertinent immune complexes. Rheumatoid arthritis autoantibodies bind with higher affinity at febrile/inflammation temperatures. Fever may modulate binding affinity of autoantibodies relevant for rheumatoid arthritis.