The relationship of salusins with Parkinson's Disease, Alzheimer's Disease, and acute ischemic stroke: A preliminary study

•Salusins are bioactive neuropeptides present in many parts of the brain.•Salusins are associated with age, lipid profile, leukocyte level.•Salusin-β is associated with Alzheimer's - Parkinson's Disease and stroke. Neuroinflammation, oxidative stress, and apoptosis play important roles in the pathophysiology of Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and Acute Ischemic Stroke (AIS). Salusin-α and salusin-β peptides, which were shown to be present in many tissues, including the central nervous system, were also shown to be associated with apoptosis, inflammation, and oxidative stress. In the present study, the relationship between Salusin-α and salusin-β peptides and AD, PD, and AIS were investigated. A total of 179 people were included in the present study, including 46 AD, 44 PD, 42 AIS, and 47 controls. Plasma Salusin-α and salusin-β levels were measured with the ELISA Method. The plasma salusin-β levels of AD, PD, and AIS patients were lower than the control group at significant levels (p