Prognostication in Lymph Node-Positive Prostate Cancer with No PSA Persistence After Radical Prostatectomy

Prognostication in Lymph Node-Positive Prostate Cancer with No PSA Persistence After Radical Prostatectomy

Background This study aimed to create a prognostic model to predict disease recurrence among patients with lymph node involvement but no prostate-specific antigen (PSA) persistence and to explore its clinical utility. Methods The study analyzed patients with lymph node involvement after pelvic lymph...

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Veröffentlicht in:Annals of surgical oncology 2024-06, Vol.31 (6), p.3872-3879
Hauptverfasser: Shiota, Masaki, Takamatsu, Dai, Matsui, Yoshiyuki, Yokomizo, Akira, Morizane, Shuichi, Saito, Ryoichi, Miyake, Makito, Tsutsumi, Masakazu, Yamamoto, Yoshiyuki, Tashiro, Kojiro, Tomida, Ryotaro, Narita, Shintaro, Edamura, Kohei, Yamaguchi, Takahiro, Hashimoto, Kohei, Kato, Masashi, Kasahara, Takashi, Yoshino, Takayuki, Akamatsu, Shusuke, Kaneko, Tomoyuki, Matsukawa, Akihiro, Matsumoto, Ryuji, Joraku, Akira, Saito, Toshihiro, Kato, Takuma, Kato, Manabu, Enokida, Hideki, Sakamoto, Shinichi, Terada, Naoki, Kanno, Hidenori, Nishiyama, Naotaka, Kimura, Takahiro, Kitamura, Hiroshi, Eto, Masatoshi
Format: Artikel
Sprache:eng
Schlagworte:
Lymph nodes
Lymphatic system
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Oncology
Patients
Prostate cancer
Prostate-specific antigen
Prostatectomy
Surgery
Surgical Oncology
Survival
Urologic Oncology
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Zusammenfassung:Background This study aimed to create a prognostic model to predict disease recurrence among patients with lymph node involvement but no prostate-specific antigen (PSA) persistence and to explore its clinical utility. Methods The study analyzed patients with lymph node involvement after pelvic lymph node dissection with radical prostatectomy in whom no PSA persistence was observed between 2006 and 2019 at 33 institutions. Prognostic factors for recurrence-free survival (RFS) were analyzed by the Cox proportional hazards model. Results Among 231 patients, 127 experienced disease recurrence. The factors prognostic for RFS were PSA level at diagnosis (≥ 20 vs.
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-024-14999-2