A systematic review focused on lubricant use and sperm quality: Improving human reproductive success by informing lubricants toxicity

Lubricants play a pivotal role in human reproductive health, particularly concerning their impact on sperm parameters. In this systematic review, we assess the implications of both synthetic and natural or organic lubricants on sperm health and fertility, based on a compilation of 20 distinct studies. Synthetic lubricants, including K‐Y Jelly, Replens, and Astroglide, predominantly containing ingredients like methylparaben and glycerin, have been linked to detrimental effects on sperm motility and chromatin integrity. Chemical characteristics, notably osmolality and pH, are central to understanding these effects. Despite the World Health Organization's osmolality recommendation of 380 mOsm/kg, many commercial products surpass this. Natural solutions offer varied results, while olive oil exhibits unfavorable effects on sperm health, egg white proves non‐toxic, potentially benefitting sperm health. Conversely, Pre‐Seed, widely endorsed in the research community, generally demonstrates minimal adverse impact on sperm. The review highlights the significance of lubricant selection in evidence‐based reproductive strategies. Lubricants have a marked effect on sperm health. In this systematic review encompassing 20 studies, synthetic products such as K‐Y Jelly and Astroglide often compromise sperm attributes due to their ingredients and chemistry. On the other hand, natural options vary: Olive oil poses risks, while egg white appears neutral. Pre‐Seed, a research‐favored product, presents minimal concerns. This review emphasizes the need for evidence‐based lubricant selection in reproductive planning.