Identification of Central Genes and Regulatory Pathways Associated with Hyperlipidemia in Rats

Hyperlipidemia is an independent risk factor for cardiovascular and cerebrovascular diseases. The transcriptomic data and the gene regulatory networks of hyperlipidemia are largely unclear. We analyzed the changes in liver gene expression and the serum levels of biochemical indicators in rats with h...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochemical genetics 2024-12, Vol.62 (6), p.4693-4709
Hauptverfasser: Fu, Xinyue, Song, Xinni, Niu, Shufang, Liu, Jiali, Shi, Songli, Chang, Hong, Zhang, Chuanming, Qi, Jun, Wang, Peng, Bai, Yingchun, Bai, Wanfu
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Hyperlipidemia is an independent risk factor for cardiovascular and cerebrovascular diseases. The transcriptomic data and the gene regulatory networks of hyperlipidemia are largely unclear. We analyzed the changes in liver gene expression and the serum levels of biochemical indicators in rats with hyperlipidemia induced by high-fat diet (HFD). The body weight, liver weight, and the serum levels of TG, TC, HDL-C, LDL-C, ALT, and AST were significantly higher in the hyperlipidemic rats compared to the healthy controls ( P  
ISSN:0006-2928
1573-4927
1573-4927
DOI:10.1007/s10528-024-10685-w