Dual-sgRNA CRISPRa System for Enhanced MK‑7 Production and Salmonella Infection Mitigation in Bacillus subtilis natto Applied to Caco‑2 Cells

This study optimized the menaquinone-7 (MK-7) synthetic pathways in Bacillus subtilis (B. subtilis) natto NB205, a strain that originated from natto, to enhance its MK-7 production. Utilizing mutation breeding, we developed NBMK308, a mutant strain that demonstrated a significant 117.23% increase in...

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Veröffentlicht in:Journal of agricultural and food chemistry 2024-02, Vol.72 (8), p.4301-4316
Hauptverfasser: Liao, Chaoyong, Cui, Jian, Gao, Mingkun, Wang, Bo, Ito, Koichi, Guo, Yuming, Zhang, Bingkun
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Sprache:eng
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