Force spectroscopy measurements of MoSIx nanowires with functionalized molecules

We report a simple method of functionalization of MoSIx nanowires with biomaterials via the thiol group. We succeed to immobilize iodinated and sulphated high molecular mass thyroglobulin proteins on MoSIx nanowires. By controlling the preparation of the nanowires before self‐assembly we can attach...

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Veröffentlicht in:	Physica Status Solidi (b) 2006-11, Vol.243 (13), p.3325-3328
Hauptverfasser:	Ploscaru, M., Kokalj, Sasa Jenko, Uplaznik, M., Vengust, D., Turk, D., Mihailovic, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	36.20.−r 68.37.Ps 81.07.−b 87.14.Ee Biological and medical sciences Cross-disciplinary physics: materials science rheology Exact sciences and technology Fundamental and applied biological sciences. Psychology Interactions. Associations Intermolecular phenomena Materials science Molecular biophysics Nanoscale materials and structures: fabrication and characterization Nanotubes Physics
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Beschreibung
Zusammenfassung:	We report a simple method of functionalization of MoSIx nanowires with biomaterials via the thiol group. We succeed to immobilize iodinated and sulphated high molecular mass thyroglobulin proteins on MoSIx nanowires. By controlling the preparation of the nanowires before self‐assembly we can attach proteins either at the ends or achieve complete wrapping of the nanowires. The control parameter is the S and I stoichiometry ratio of the MoSIx nanowires. Breaking force measurements were performed in order to confirm and characterise the wrapping of the nanowires with the proteins. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
ISSN:	0370-1972 1521-3951
DOI:	10.1002/pssb.200669204