Spectrum of Liver Injury in Dengue Fever: Cause or Effect of Severe Dengue?
The study aimed to determine if deranged liver function tests (LFTs) can predict severe dengue or mortality. It included 135 dengue patients, with a mean age of 30.9 ± 12.09 years. Among the patients, 82 (60.7%) were under 30 years of age. Nearly half of the patients (64, 47. 4%) had some degree of...
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| Veröffentlicht in: | Journal of the College of Physicians and Surgeons--Pakistan 2024-02, Vol.34 (2), p.241-243 |
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| container_title | Journal of the College of Physicians and Surgeons--Pakistan |
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| creator | Khattak, Muhammad Irfan Khattak, Samina Naseem Khattak, Muhammad Numan Hadi, Shumaila Numan Rafique, Muhammad Baloch, Sherbano |
| description | The study aimed to determine if deranged liver function tests (LFTs) can predict severe dengue or mortality. It included 135 dengue patients, with a mean age of 30.9 ± 12.09 years. Among the patients, 82 (60.7%) were under 30 years of age. Nearly half of the patients (64, 47. 4%) had some degree of liver damage indicated by deranged LFTs, 27 (42.1%) had elevated alanine transaminase (ALT), 7 (10.9%) had increased bilirubin, and 30 (46.9%) had high values of alkaline phosphatase (ALP). However, only elevated ALP levels were positively correlated with mortality (Pearson's R = 0.282, p = |
| doi_str_mv | 10.29271/jcpsp.2024.02.241 |
| format | Article |
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It included 135 dengue patients, with a mean age of 30.9 ± 12.09 years. Among the patients, 82 (60.7%) were under 30 years of age. Nearly half of the patients (64, 47. 4%) had some degree of liver damage indicated by deranged LFTs, 27 (42.1%) had elevated alanine transaminase (ALT), 7 (10.9%) had increased bilirubin, and 30 (46.9%) had high values of alkaline phosphatase (ALP). However, only elevated ALP levels were positively correlated with mortality (Pearson's R = 0.282, p = <0.05). The mean bilirubin was 11.711 ± 8.602 umol/l, and the mean values of ALT and ALP were 107 ± 240 and 113.571 ± 59.91 IU/L, respectively, which were higher than the normal. The study findings suggested that hepatic derangement is a common occurrence in dengue patients, and increased ALP levels could be an indicator of a higher risk of mortality. These findings can help improve patient care by identifying the potential risk factors for mortality. 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It included 135 dengue patients, with a mean age of 30.9 ± 12.09 years. Among the patients, 82 (60.7%) were under 30 years of age. Nearly half of the patients (64, 47. 4%) had some degree of liver damage indicated by deranged LFTs, 27 (42.1%) had elevated alanine transaminase (ALT), 7 (10.9%) had increased bilirubin, and 30 (46.9%) had high values of alkaline phosphatase (ALP). However, only elevated ALP levels were positively correlated with mortality (Pearson's R = 0.282, p = <0.05). The mean bilirubin was 11.711 ± 8.602 umol/l, and the mean values of ALT and ALP were 107 ± 240 and 113.571 ± 59.91 IU/L, respectively, which were higher than the normal. The study findings suggested that hepatic derangement is a common occurrence in dengue patients, and increased ALP levels could be an indicator of a higher risk of mortality. These findings can help improve patient care by identifying the potential risk factors for mortality. Key Words: Dengue, Liver function tests, Alanine transaminase, Alkaline phosphatase.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alanine Transaminase</subject><subject>Alkaline Phosphatase</subject><subject>Aspartate Aminotransferases</subject><subject>Bilirubin</subject><subject>Complications and side effects</subject><subject>Dengue</subject><subject>Dengue - complications</subject><subject>Dengue - diagnosis</subject><subject>Development and progression</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Liver Function Tests</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Pakistan</subject><subject>Phosphatases</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>Severe Dengue - complications</subject><subject>Severe Dengue - diagnosis</subject><subject>Young Adult</subject><issn>1022-386X</issn><issn>1681-7168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkctKAzEYRoMoVqsv4EICbtzMmMtkJuNGSm21WHBRBXchzfwpUzoXk47Qtze9KAgSSMKXc0LIh9AVJTHLWUbvlqb1bcwIS2LCYpbQI3RGU0mjLMzHYU8Yi7hMP3ro3PslIVxQKU9Rj0ueMCnpGXqZtWDWrqtwY_G0_AKHJ_Wycxtc1vgR6kUHeAwhvsdD3XnAjcMja4OzFWbbEzhwDxfoxOqVh8vD2kfv49Hb8Dmavj5NhoNpZHgq1lE6z1MmTAGZNDRPKLUgDUtBhMRQJm2RAxdE2ERSCVaDZlzOi7zQ1nJmCt5Ht_t7W9d8duDXqiq9gdVK19B0XoXPEYlMhKABvdmjC70CVda2WTtttrgaZFLwjOSEByr-hwqjgKo0TQ22DPkfge0F4xrvHVjVurLSbqMoUbtu1K4bte1GEaZCN0G6Pjy7m1dQ_Co_ZfBvRXSJVQ</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Khattak, Muhammad Irfan</creator><creator>Khattak, Samina Naseem</creator><creator>Khattak, Muhammad Numan</creator><creator>Hadi, Shumaila Numan</creator><creator>Rafique, Muhammad</creator><creator>Baloch, Sherbano</creator><general>College of Physicians and Surgeons Pakistan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202402</creationdate><title>Spectrum of Liver Injury in Dengue Fever: Cause or Effect of Severe Dengue?</title><author>Khattak, Muhammad Irfan ; Khattak, Samina Naseem ; Khattak, Muhammad Numan ; Hadi, Shumaila Numan ; Rafique, Muhammad ; Baloch, Sherbano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-6b9625cde78c19411fe8c26e5de7c128fd9e3505f4818efaea238bd9daff32cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alanine Transaminase</topic><topic>Alkaline Phosphatase</topic><topic>Aspartate Aminotransferases</topic><topic>Bilirubin</topic><topic>Complications and side effects</topic><topic>Dengue</topic><topic>Dengue - complications</topic><topic>Dengue - diagnosis</topic><topic>Development and progression</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Liver Function Tests</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mortality</topic><topic>Pakistan</topic><topic>Phosphatases</topic><topic>Prognosis</topic><topic>Risk factors</topic><topic>Severe Dengue - complications</topic><topic>Severe Dengue - diagnosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khattak, Muhammad Irfan</creatorcontrib><creatorcontrib>Khattak, Samina Naseem</creatorcontrib><creatorcontrib>Khattak, Muhammad Numan</creatorcontrib><creatorcontrib>Hadi, Shumaila Numan</creatorcontrib><creatorcontrib>Rafique, Muhammad</creatorcontrib><creatorcontrib>Baloch, Sherbano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khattak, Muhammad Irfan</au><au>Khattak, Samina Naseem</au><au>Khattak, Muhammad Numan</au><au>Hadi, Shumaila Numan</au><au>Rafique, Muhammad</au><au>Baloch, Sherbano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spectrum of Liver Injury in Dengue Fever: Cause or Effect of Severe Dengue?</atitle><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle><addtitle>J Coll Physicians Surg Pak</addtitle><date>2024-02</date><risdate>2024</risdate><volume>34</volume><issue>2</issue><spage>241</spage><epage>243</epage><pages>241-243</pages><issn>1022-386X</issn><eissn>1681-7168</eissn><abstract>The study aimed to determine if deranged liver function tests (LFTs) can predict severe dengue or mortality. It included 135 dengue patients, with a mean age of 30.9 ± 12.09 years. Among the patients, 82 (60.7%) were under 30 years of age. Nearly half of the patients (64, 47. 4%) had some degree of liver damage indicated by deranged LFTs, 27 (42.1%) had elevated alanine transaminase (ALT), 7 (10.9%) had increased bilirubin, and 30 (46.9%) had high values of alkaline phosphatase (ALP). However, only elevated ALP levels were positively correlated with mortality (Pearson's R = 0.282, p = <0.05). The mean bilirubin was 11.711 ± 8.602 umol/l, and the mean values of ALT and ALP were 107 ± 240 and 113.571 ± 59.91 IU/L, respectively, which were higher than the normal. The study findings suggested that hepatic derangement is a common occurrence in dengue patients, and increased ALP levels could be an indicator of a higher risk of mortality. These findings can help improve patient care by identifying the potential risk factors for mortality. 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| issn | 1022-386X 1681-7168 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Alanine Transaminase Alkaline Phosphatase Aspartate Aminotransferases Bilirubin Complications and side effects Dengue Dengue - complications Dengue - diagnosis Development and progression Health aspects Humans Liver Liver diseases Liver Function Tests Medical research Medicine, Experimental Mortality Pakistan Phosphatases Prognosis Risk factors Severe Dengue - complications Severe Dengue - diagnosis Young Adult |
| title | Spectrum of Liver Injury in Dengue Fever: Cause or Effect of Severe Dengue? |
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