Biomimetic microfluidic chips for toxicity assessment of environmental pollutants

Various types of pollutants widely present in environmental media, including synthetic and natural chemicals, physical pollutants such as radioactive substances, ultraviolet rays, and noise, as well as biological organisms, pose a huge threat to public health. Therefore, it is crucial to accurately and effectively explore the human physiological responses and toxicity mechanisms of pollutants to prevent diseases caused by pollutants. The emerging toxicological testing method biomimetic microfluidic chips (BMCs) exhibit great potential in environmental pollutant toxicity assessment due to their superior biomimetic properties. The BMCs are divided into cell-on-chips and organ-on-chips based on the distinctions in bionic simulation levels. Herein, we first summarize the characteristics, emergence and development history, composition and structure, and application fields of BMCs. Then, with a focus on the toxicity mechanisms of pollutants, we review the applications and advances of the BMCs in the toxicity assessment of physical, chemical, and biological pollutants, respectively, highlighting its potential and development prospects in environmental toxicology testing. Finally, the opportunities and challenges for further use of BMCs are discussed. [Display omitted] •The key elements of BMC design and manufacturing are reviewed.•Details and results on the toxicity assessment of environmental pollutants by BMCs are provided.•BMCs are divided into cell-on-chips and organ-on-chips based on biomimetic levels.•Pollutants affect health at both molecular and cellular/tissue levels.•BMCs are emerging tools for toxicity evaluation with broad prospects.