Benefits of influenza vaccine on stroke beyond preventing infection: Paradigm change or sheer bias?

A growing body of literature provides evidence, nonetheless, that seasonal influenza may transiently increase the risk of ischemic stroke. [] Thromboinflammation, a procoagulant state driven by inflammatory response to influenza and other viruses, is a likely mechanism for this increased risk []. Th...

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Veröffentlicht in:European journal of neurology 2024-04, Vol.31 (4), p.e16239-n/a
Hauptverfasser: Elkind, Mitchell S. V., Abajo, Francisco J.
Format: Artikel
Sprache:eng
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Zusammenfassung:A growing body of literature provides evidence, nonetheless, that seasonal influenza may transiently increase the risk of ischemic stroke. [] Thromboinflammation, a procoagulant state driven by inflammatory response to influenza and other viruses, is a likely mechanism for this increased risk []. The investigators conducted a large-scale administrative database study in Alberta, Canada, using health insurance data on all adults in the province, covering the period from September 2009 to December 2018. A possible direct effect of influenza vaccination was also suggested by Rodríguez-Martín et al. [], in a nested case–control study utilizing a nationally representative primary care database from Spain that analyzed the relationship of influenza vaccination and ischemic stroke during pre-epidemic, epidemic, and post-epidemic periods over 15 influenza seasons (2002–2015). Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 Guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association.
ISSN:1351-5101
1468-1331
1468-1331
DOI:10.1111/ene.16239