Incidence and risk factors for developing chemotherapy‐induced neuropathic pain in 500 cancer patients: A file‐based observational study

Objective To define the incidence and risk factors for developing chemotherapy‐induced neuropathic pain (CINP). Methods Retrospective, file‐based analysis on cancer patients who received any type of conventional chemotherapy and for whom neurological evaluation was asked to reveal the extent of chemotherapy‐induced peripheral neurotoxicity (CIPN) with or without CINP. CINP was assessed by means of the PI‐NRS and Douleur Neuropathique‐4 questionnaire. The total neuropathy score‐clinical version graded the severity of CIPN. Results The medical files of 500 chemotherapy‐treated cancer patients were reviewed. Any grade chronic CIPN was disclosed in 343 (68.6%) patients and CINP in 127 (37%) of them, corresponding to an overall percentage of 25.4% among all 500 included patients. The logistic regression analysis identified as independent predictors for CINP development the presence of uncomplicated diabetes (OR: 2.17; p = .039) and grade 2–3 chronic CIPN (OR: 1.61; p