Polystyrene microplastics mitigate lead-induced neurotoxicity by reducing heavy metal uptake in zebrafish larvae

Polystyrene microplastics mitigate lead-induced neurotoxicity by reducing heavy metal uptake in zebrafish larvae

The combined pollution of lead (Pb) and polystyrene microplastics (PS-MPs) is common in aquatic environments. However, the combined neurotoxicity of these two pollutants is still poorly understood. In this study, zebrafish (Danio rerio) larvae were used to assess the combined neurotoxicity and mecha...

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Veröffentlicht in:The Science of the total environment 2024-04, Vol.919, p.170790-170790, Article 170790
Hauptverfasser: Cao, Qiyue, Wei, Dongqiong, Ma, Xuan, Liu, Rongjian, Samra, Qi, Yongmei, Yuan, Cong, Huang, Dejun
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Deferoxamine (DFO)
Divalent metal transporter 1
Larva - metabolism
Lead
Lead - metabolism
Lead - toxicity
Metals, Heavy - metabolism
Microplastics
Microplastics - metabolism
Microplastics - toxicity
Neurobehavior
Neurodevelopment-related genes
Plastics - toxicity
Polystyrenes - metabolism
Polystyrenes - toxicity
Water Pollutants, Chemical - metabolism
Water Pollutants, Chemical - toxicity
Zebrafish - physiology
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Zusammenfassung:The combined pollution of lead (Pb) and polystyrene microplastics (PS-MPs) is common in aquatic environments. However, the combined neurotoxicity of these two pollutants is still poorly understood. In this study, zebrafish (Danio rerio) larvae were used to assess the combined neurotoxicity and mechanism of Pb and PS-MPs at environmentally relevant concentrations. The results showed that Pb (10 μg/L) induced abnormal behavior including significantly reduced movement distance, maximum acceleration, and average velocity (P 
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2024.170790