WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis

Idiopathic pulmonary fibrosis is a progressive interstitial lung disease for which there is no curative therapy available. Repetitive alveolar epithelial injury repair, myofibroblast accumulation, and excessive collagen deposition are key pathologic features of idiopathic pulmonary fibrosis, eventua...

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Veröffentlicht in:	The American journal of pathology 2024-05, Vol.194 (5), p.656-672
Hauptverfasser:	Chong, Lei, Zou, Lihui, Xiang, Liyan, Song, Xinyue, Miao, Wanqi, Yan, Xihua, Xu, Ming, Ling, Gongxia, El Agha, Elie, Bellusci, Saverio, Lou, Zhenkun, Zhang, Hailin, Zhang, Jin-San
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bleomycin - toxicity Fibrosis Hypoxia - pathology Idiopathic Pulmonary Fibrosis - pathology Intracellular Signaling Peptides and Proteins Lung - pathology Lung Injury - pathology Mice Myofibroblasts - metabolism Proteomics Regeneration Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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