Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection

Tenecteplase for thrombolysis in a 4.5-to-24-hour window did not improve disability outcomes at 90 days in patients with ischemic stroke who had been chosen on the basis of imaging. Most patients had endovascular thrombectomy.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2024-02, Vol.390 (8), p.701-711
Hauptverfasser:	Albers, Gregory W., Jumaa, Mouhammad, Purdon, Barbara, Zaidi, Syed F., Streib, Christopher, Shuaib, Ashfaq, Sangha, Navdeep, Kim, Minjee, Froehler, Michael T., Schwartz, Neil E., Clark, Wayne M., Kircher, Charles E., Yang, Ming, Massaro, Lori, Lu, Xiao-Yu, Rippon, Gregory A., Broderick, Joseph P., Butcher, Ken, Lansberg, Maarten G., Liebeskind, David S., Nouh, Amre, Schwamm, Lee H., Campbell, Bruce C.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Body weight Brain - blood supply Brain - diagnostic imaging Brain Ischemia - diagnostic imaging Brain Ischemia - drug therapy Brain Ischemia - mortality Brain Ischemia - surgery Cardiovascular system Carotid arteries Carotid artery Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - drug therapy Carotid Artery Diseases - surgery Cerebral blood flow Clinical trials Design Double-Blind Method Emergency Medicine FDA approval Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - adverse effects Fibrinolytic Agents - therapeutic use Hemorrhage Humans Infarction, Middle Cerebral Artery - diagnostic imaging Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - surgery Intracranial Hemorrhages - chemically induced Intracranial Hemorrhages - diagnostic imaging Ischemia Ischemic Stroke - diagnostic imaging Ischemic Stroke - drug therapy Ischemic Stroke - mortality Ischemic Stroke - surgery Magnetic resonance imaging Medical imaging Neurology Neurosurgery Patients Perfusion Perfusion Imaging - methods Placebos Stroke Stroke - diagnostic imaging Stroke - drug therapy Stroke - mortality Stroke - surgery Tenecteplase - administration & dosage Tenecteplase - adverse effects Tenecteplase - therapeutic use Thrombectomy - adverse effects Thrombectomy - methods Thrombolysis Thrombolytic drugs Time-to-Treatment Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - adverse effects Tissue Plasminogen Activator - therapeutic use Treatment Outcome Veins & arteries
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Beschreibung
Zusammenfassung:	Tenecteplase for thrombolysis in a 4.5-to-24-hour window did not improve disability outcomes at 90 days in patients with ischemic stroke who had been chosen on the basis of imaging. Most patients had endovascular thrombectomy.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2310392