Neonatal SARS-CoV-2 immunoglobulin G antibodies at delivery and their impact on COVID-19

Neonatal SARS-CoV-2 immunoglobulin G antibodies at delivery and their impact on COVID-19

Objective To assess neonatal SARS-CoV-2 anti-spike IgG antibody levels after maternal mRNA COVID-19 vaccination and/or infection during pregnancy and evaluate their protective effect. Methods Prospective observational study, conducted from January 2021 to December 2022. Infants were tested for anti-...

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Veröffentlicht in:European journal of clinical microbiology & infectious diseases 2024-04, Vol.43 (4), p.693-702
Hauptverfasser: Vetter-Laracy, Susanne, Jimenez, Victoria, Roldán, Marina, Bernardino, Marta, Balliu-Badia, Pere, Lara, Paula, Arcay, Ricardo Manuel, Fraile-Ribot, Pablo, Vila, Maria, Fanjul, Francisco
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Antibodies, Viral
Biomedical and Life Sciences
Biomedicine
COVID-19
COVID-19 Vaccines
Disease transmission
Female
Gestational age
Humans
IgG antibody
Immunoglobulin G
Infant
Infant, Newborn
Infants
Infections
Internal Medicine
Medical Microbiology
mRNA
Neonates
Newborn babies
Observational studies
Original Article
Pregnancy
Pregnancy Complications, Infectious
Risk groups
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccination
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Zusammenfassung:Objective To assess neonatal SARS-CoV-2 anti-spike IgG antibody levels after maternal mRNA COVID-19 vaccination and/or infection during pregnancy and evaluate their protective effect. Methods Prospective observational study, conducted from January 2021 to December 2022. Infants were tested for anti-spike IgG antibodies at birth and then every 3 months until disappearance of titer. A follow-up was done for SARS-CoV-2 infection up to 12 months. Results In total, 147 newborns were enrolled with a median (IQR) gestational age of 39.60 weeks (38.3–40.4). Median (IQR) titers in UA/ml at 2 days were higher ( P  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-024-04773-3