Clinical Characteristics, Outcomes, and Risk Factors for Mortality in Pregnant/Puerperal Women with COVID-19 Admitted to ICU in Turkey: A Multicenter, Retrospective Study from a Middle-Income Country

Background Coronaviruses have been the cause of 3 major outbreaks during the last 2 decades. Information on coronavirus diseases in pregnant women is limited, and even less is known about seriously ill pregnant women. Data are also lacking regarding the real burden of coronavirus disease 2019 (COVID...

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Veröffentlicht in:Journal of intensive care medicine 2024-06, Vol.39 (6), p.577-594
Hauptverfasser: Baykara, Nur, Arslantaş, Mustafa Kemal, Hancı, Volkan, Akalın, Halis, Demirkıran, Oktay, Bozbay, Suha, Ergül, Dursun Fırat, Arslantaş, Reyhan, Balcı, Sibel, Alparslan, Volkan, Topal, Serra, Çalışkan, Gülbahar, Yakışık, Esra, İzdeş, Seval, erdem, Deniz, Erdem, Ali Fuat, Cırdı, Yaşar, Kuzgun, Özge, Akdağ, Gökhan, Bektaş, Şerife, Yılmaz, Mehmet, Akdağ, Devrim, Akkoyun, Didem Sözütek, Ata, Adnan, Haftacı, Engin, Peker, Aynur, Esercan, Alev, Öksüz, Hafize, Gişi, Gökçe, Metin, Esma Nur, Çelik, Jale Bengi, Çömez, Mehmet Selim, Uyan, Berna, Gündoğdu, Oğuz, Kaygusuz, Kenan, Düzgün, Ahmet, Türkyılmaz, Neşe, Çakırer, Maaşallah, Arslan, Ülkü, Yılmaz, Murat, Yüksel, Recep Civan, Kömürcü, Özgür, Tekin, Esra, Kahveci, Ferda, Akesen, Selcan, Delen, Leman Acun, Aydoğan, Burcu Başarık, Sarı, Ali, Cinel, İsmail, Gül, Fethi, Şanlı, Deniz, Saraçoğlu, Tolga, Demirağ, Kubilay, Uyar, Mehmet, Çankayalı, İlkin, Baydemir, Canan, Doğan, Yasemin, Güler, Özlem, Kurt, İbrahim, Yılmaz, Pakize Özçiftçi, Uluç, Kamuran, Karabacak, Pakize Kırdemir,Pınar, Tuna, Verda, Beştaş, Azize, Demirel, İsmail, Özer, Ayşe Belin, Ayoğlu, Hilal, Bollucuoğlu, Keziban, Kasapoğlu, Umut Sabri, Kılıç, Özgür, Altay, Nuray, Küçük, Murat, Gökçe, Recep, Atlı, Zeynep, Dumanlı, Güleren Yartaş, Yelken, Birgül Büyükkıdan, Karakoç, Ebru, Gökmen, Necati, Serin, Simay, Sungurtekin, Hülya, Sevdi, Mehmet Salih, Zinciroğlu, Çiler, Balcı, Canan, Çoruh, Aliye Esmaoğlu, Öztürk, Nilgün Kavrut, Arar, Cavidan, Yıldırım, İlker, Özdemir, Abdullah
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Sprache:eng
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Zusammenfassung:Background Coronaviruses have been the cause of 3 major outbreaks during the last 2 decades. Information on coronavirus diseases in pregnant women is limited, and even less is known about seriously ill pregnant women. Data are also lacking regarding the real burden of coronavirus disease 2019 (COVID-19) infection in pregnant women from low/middle-income countries. The aim of this study was to determine the characteristics and clinical course of COVID-19 in pregnant/puerperal women admitted to ICUs in Turkey. Methods This was a national, multicenter, retrospective study. The study population comprised all SARS-CoV-2-infected pregnant/puerperal women admitted to participating ICUs between 1 March 2020 and 1 January 2022. Data regarding demographics, comorbidities, illness severity, therapies, extrapulmonary organ injuries, non-COVID-19 infections, and maternal and fetal/neonatal outcomes were recorded. LASSO logistic regression and multiple logistic regression analyses were used to identify predictive variables in terms of ICU mortality. Results A total of 597 patients (341 pregnant women, 255 puerperal women) from 59 ICUs in 44 hospitals were included and of these patients, 87.1% were unvaccinated. The primary reason for ICU admission was acute hypoxemic respiratory failure in 522 (87.4%), acute hypoxemic respiratory failure plus shock in 14 (2.3%), ischemic cerebrovascular accident (CVA) in 5 (0.8%), preeclampsia/eclampsia/HELLP syndrome in 6 (1.0%), and post-caesarean follow-up in 36 (6.0%). Nonsurvivors were sicker than survivors upon ICU admission, with higher APACHE II (p 
ISSN:0885-0666
1525-1489
DOI:10.1177/08850666231222838