Releasing the TLE3 break to put TCM cells on a fast track
The transcription cofactor TLE3 interacts with RUNX3 and TCF1 to repress the transcription and chromatin accessibility of CD8 + T CM cell signature genes, while simultaneously acting as a coactivator for TBET to facilitate the expression of CD8 + T EM cell signature genes. As such, TLE3 serves as a...
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| Veröffentlicht in: | Nature immunology 2024-02, Vol.25 (2), p.191-193 |
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| container_title | Nature immunology |
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| creator | Shen, Jian Lin, Siying Cui, Weiguo |
| description | The transcription cofactor TLE3 interacts with RUNX3 and TCF1 to repress the transcription and chromatin accessibility of CD8
+
T
CM
cell signature genes, while simultaneously acting as a coactivator for TBET to facilitate the expression of CD8
+
T
EM
cell signature genes. As such, TLE3 serves as a gatekeeper of CD8
+
T
CM
cell formation. |
| doi_str_mv | 10.1038/s41590-023-01732-6 |
| format | Article |
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+
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CM
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| ispartof | Nature immunology, 2024-02, Vol.25 (2), p.191-193 |
| issn | 1529-2908 1529-2916 |
| language | eng |
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| source | Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 631/250/1619/554/1834 631/250/2152/1566/1571 631/250/2502/2170 631/250/255/2514 Biomedical and Life Sciences Biomedicine CD8 antigen Cells Chromatin Genes Genetic engineering Hepatocyte nuclear factor 1 Immunology Infections Infectious Diseases Lymphocytes News & Views news-and-views Pathogens Proteins Runx3 protein Transcription factors Tumors Vaccines |
| title | Releasing the TLE3 break to put TCM cells on a fast track |
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