Releasing the TLE3 break to put TCM cells on a fast track

Releasing the TLE3 break to put TCM cells on a fast track

The transcription cofactor TLE3 interacts with RUNX3 and TCF1 to repress the transcription and chromatin accessibility of CD8 + T CM cell signature genes, while simultaneously acting as a coactivator for TBET to facilitate the expression of CD8 + T EM cell signature genes. As such, TLE3 serves as a...

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Veröffentlicht in:Nature immunology 2024-02, Vol.25 (2), p.191-193
Hauptverfasser: Shen, Jian, Lin, Siying, Cui, Weiguo
Format: Artikel
Sprache:eng
Schlagworte:
631/250/1619/554/1834
631/250/2152/1566/1571
631/250/2502/2170
631/250/255/2514
Biomedical and Life Sciences
Biomedicine
CD8 antigen
Cells
Chromatin
Genes
Genetic engineering
Hepatocyte nuclear factor 1
Immunology
Infections
Infectious Diseases
Lymphocytes
News & Views
news-and-views
Pathogens
Proteins
Runx3 protein
Transcription factors
Tumors
Vaccines
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Zusammenfassung:The transcription cofactor TLE3 interacts with RUNX3 and TCF1 to repress the transcription and chromatin accessibility of CD8 + T CM cell signature genes, while simultaneously acting as a coactivator for TBET to facilitate the expression of CD8 + T EM cell signature genes. As such, TLE3 serves as a gatekeeper of CD8 + T CM cell formation.
ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-023-01732-6