Effect of smoking on methylation and semen parameters

Effect of smoking on methylation and semen parameters

One type of epigenetic modification is genomic DNA methylation, which is induced by smoking, and both are associated with male infertility. In this study, the relationship between smoking and CHD5 gene methylation and semen parameters in infertile men was determined. After the MS‐PCR of blood in 224...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Environmental and molecular mutagenesis 2024-01, Vol.65 (1-2), p.76-83
Hauptverfasser: Naeimi, Nasim, Mohseni Kouchesfehani, Homa, Heidari, Zahra, Mahmoudzadeh‐Sagheb, Hamidreza
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Body fluids
cigarette‐smoking
DNA Helicases
DNA methylation
DNA Methylation - genetics
Epigenetics
Health risks
Humans
Infertility
Infertility, Male - genetics
Male
Nerve Tissue Proteins
Nicotine
Parameter modification
Risk factors
Semen
Semen Analysis
semen parameters
Smoking
Smoking - adverse effects
Smoking - genetics
Spermatozoa
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:One type of epigenetic modification is genomic DNA methylation, which is induced by smoking, and both are associated with male infertility. In this study, the relationship between smoking and CHD5 gene methylation and semen parameters in infertile men was determined. After the MS‐PCR of blood in 224 samples, 103 infertile patients (62 smokers and 41 non‐smokers) and 121 fertile men, methylation level changes between groups and the effect of methylation and smoking on infertility and semen parameters in infertile men were determined. The results showed that there is a significant difference in the methylation status (MM, MU, UU) of the CHD5 gene between the patient and the control group, and this correlation also exists for the semen parameters (p 
ISSN:0893-6692
1098-2280
DOI:10.1002/em.22583