Does YAP influence cell proliferation and apoptosis in benign epithelial odontogenic lesions?

Objective To analyze the immunohistochemical expression of YAP and its correlation with markers involved in cell proliferation and apoptosis in benign epithelial odontogenic lesions. Study Design The sample consisted of 95 cases of odontogenic lesions (25 dentigerous cysts, 30 non‐syndromic odontoge...

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Veröffentlicht in:Oral diseases 2024-10, Vol.30 (7), p.4538-4546
Hauptverfasser: Gonçalo, Rani Iani Costa, Sousa, Julliany Taverny, Costa, Carla Samily de Oliveira, Mafra, Rodrigo Porpino, Santos, Janaina Lessa de Moraes dos, Silva, Leorik Pereira, Queiroz, Lélia Maria Guedes
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Sprache:eng
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Zusammenfassung:Objective To analyze the immunohistochemical expression of YAP and its correlation with markers involved in cell proliferation and apoptosis in benign epithelial odontogenic lesions. Study Design The sample consisted of 95 cases of odontogenic lesions (25 dentigerous cysts, 30 non‐syndromic odontogenic keratocysts, 30 conventional ameloblastomas, and 10 unicystic ameloblastomas) and 10 dental follicles used as normal odontogenic tissue. The histological sections were submitted to immunohistochemistry with YAP, cyclin D1, Ki‐67, and Bcl‐2 antibodies. Immunoexpression was analyzed qualitatively and quantitatively using an adapted method. The collected data were analyzed descriptively and statistically (p ≤ 0.05). Results The highest YAP expression was observed in odontogenic keratocysts, followed by unicystic ameloblastomas and conventional ameloblastomas, which exhibited moderate immunoreactivity predominantly in peripheral cells. Furthermore, significant differences in YAP immunoexpression were observed between the groups analyzed, with significant positive correlations between YAP and cyclin D1 in dentigerous cysts and unicystic ameloblastomas and between YAP and Ki‐67 in unicystic ameloblastomas (p 
ISSN:1354-523X
1601-0825
1601-0825
DOI:10.1111/odi.14882