Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice

RNA binding motif 5 (RBM5) is a tumor suppressor in cancer but its role in the brain is unclear. We used conditional gene knockout (KO) mice to test if RBM5 inhibition in the brain affects chronic cortical brain tissue survival or function after a controlled cortical impact (CCI) traumatic brain inj...

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Veröffentlicht in:	Experimental neurology 2024-04, Vol.374, p.114690, Article 114690
Hauptverfasser:	Snyder, Kara, Dixon, C. Edward, Henchir, Jeremy, Gorse, Kiersten, Vagni, Vincent A., Janesko-Feldman, Keri, Kochanek, Patrick M., Jackson, Travis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blindness Brain - metabolism Brain Injuries - pathology Brain Injuries, Traumatic - pathology Cell Cycle Proteins - metabolism Cerebellum Cerebellum - pathology DNA-Binding Proteins - metabolism Female Gene Knockout Techniques Hippocampus Hippocampus - metabolism Learning Male Maze Learning - physiology Mice Mice, Knockout Nervous System Diseases - pathology Proteostasis RBM5 RIMS2 RNA-Binding Proteins - metabolism Splicing TBI Tumor Suppressor Proteins Vision
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Zusammenfassung:	RNA binding motif 5 (RBM5) is a tumor suppressor in cancer but its role in the brain is unclear. We used conditional gene knockout (KO) mice to test if RBM5 inhibition in the brain affects chronic cortical brain tissue survival or function after a controlled cortical impact (CCI) traumatic brain injury (TBI). RBM5 KO decreased baseline contralateral hemispheric volume (p
ISSN:	0014-4886 1090-2430 1090-2430
DOI:	10.1016/j.expneurol.2024.114690