Synthesis of the C13–C27 Fragment of Madeirolide A Using Visible-Light-Promoted Radical Cyclization

The convergent synthesis of a fully elaborated C13–C27 fragment of madeirolide A has been achieved. The key features of the synthesis include the stereocontrolled construction of both the THF and THP rings via visible-light-induced iridium-catalyzed radical cyclization and the late-stage union of the two oxacyclic subunits through nickel-catalyzed decarboxylative cross-coupling.