Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice

•γδ T cells regulate the gut microbiota.•In the absence of γδ T cells, mice develop a microbial dysbiosis with the growth of microbes involved in the metabolism of aromatic amino acids.•The gut microbiota from γδ T cell deficient mice produces high amounts of hippurate.•Hippurate reaches the brain w...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2024-03, Vol.117, p.242-254
Hauptverfasser:	Cox, Laura M., Tatematsu, Bruna K., Guo, Lydia, LeServe, Danielle S., Mayrink, Julia, Oliveira, Marilia G., Donnelly, Dustin, Fonseca, Roberta C., Lemos, Luisa, Lanser, Toby B., Rosa, Ana C., Lopes, Juliana R., Schwerdtfeger, Luke A., Ribeiro, Gabriela F.C., Lobo, Eduardo L.C., Moreira, Thais G., Oliveira, Andre G., Weiner, Howard L., Rezende, Rafael M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Behavior D1R-expressing neurons Gut microbiota Striatum γδ T cells
Online-Zugang:	Volltext
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