Pseudo-targeted lipidomics insights into lipid discrepancies between yak colostrum and mature milk based on UHPLC-Qtrap-MS

[Display omitted] •Lipid differences between yak colostrum (YC) and mature milk (YM) were analyzed.•A total of 851 lipid species from 28 lipid subclasses were identified.•Forty-three significantly different lipids (SDLs) between YC and YM were screened.•These SDLs were mainly enriched in the glycerophospholipid metabolic pathway.•Lipid species information for GLs, STs, GPs, SPs, and FAs in YC and YM was added. Yak milk is essential to maintain the normal physiological functions of herders in Tibetan areas of China. However, the lipid components of yak colostrum (YC) and mature milk (YM) have not been systematically studied. We employed a quantitative lipidomics to comprehensively describe the alterations in the milk lipid profile of lactating yaks. Herein, totally 851 lipids from 28 lipid subclasses in YC and YM were identified and screened for 43 significantly different lipids (SDLs; variable importance in projection > 1, fold change 2 with P