Removal of Bilirubin by Albumin-Fixed Polysulfone Membrane

An asymmetric polysulfone membrane with reactive group of –OH was obtained by hydrolyzing the chloromethylated polysulfone membrane, and the albumin molecules were immobilized into the membrane with a crosslinking reagent of 1,4-butanediol diglycidyl ether. The albumin-fixed membrane was used to remove lipophilic toxins, bilirubin, from the bilirubin-albumin solution. The experiment results showed that the transfer rate of bilirubin was clearly enhanced after fixing albumin into the hydroxylated polysulfone membranes. The clearance of bilirubin was 49.3%. In addition, the effect of membrane thickness on the removal of bilirubin is discussed.