A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus Curvularia aeria

A novel tricyclic polyketide, curvulanone (1), was isolated from the marine-derived fungus Curvularia aeria. The structure of 1 was determined by NMR and single-crystal X-ray crystallography. 1 had a cyclopentabenzopyranone with 3-acetic acid structure that is rarely found in natural compounds. Mono...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2024/01/18, Vol.72(1), pp.98-101
Hauptverfasser:	Kamauchi, Hitoshi, Tanaka, Mayu, Suzuki, Mitsuaki, Furukawa, Miho, Ikeda, Atsushi, Sasho, Chihiro, Kiba, Yuka, Kitamura, Masashi, Takao, Koichi, Sugita, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	acetate-malonate pathway Acetic acid Amine oxidase (flavin-containing) aromatic polyketide Crystallography Curvularia Curvularia species cyclopentabenzopyran-4-one fungal metabolite Fungi NMR Nuclear magnetic resonance Single crystals X-ray crystallography
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Zusammenfassung:	A novel tricyclic polyketide, curvulanone (1), was isolated from the marine-derived fungus Curvularia aeria. The structure of 1 was determined by NMR and single-crystal X-ray crystallography. 1 had a cyclopentabenzopyranone with 3-acetic acid structure that is rarely found in natural compounds. Monoamine oxidase and sirtuin 1 inhibitory test was exhibited and 1 showed their inhibitory activity.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c23-00723