Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases
The invention in this patent application relates to spirocyclopropane-2-carboxamide derivatives represented generally by formula 1. These compounds are positive allosteric modulators of α7 nAChR and may be useful in preventing, treating, or ameliorating central nervous system diseases and disorders...
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| Veröffentlicht in: | ACS medicinal chemistry letters 2024-01, Vol.15 (1), p.6-8 |
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| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | The invention in this patent application relates to spirocyclopropane-2-carboxamide derivatives represented generally by formula 1. These compounds are positive allosteric modulators of α7 nAChR and may be useful in preventing, treating, or ameliorating central nervous system diseases and disorders such as cognitive impairments in Alzheimer’s disease, Parkinson’s disease, schizophrenia, and L-DOPA-induced dyskinesia as well as inflammation and cough. |
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| ISSN: | 1948-5875 1948-5875 |
| DOI: | 10.1021/acsmedchemlett.3c00520 |