Performance of noninvasive fibrosis indices in chronic hepatitis B during pretreatment and post-treatment periods

Pretreatment and post-treatment performances of noninvasive fibrosis indices were determined in patients with chronic hepatitis B. This was a retrospective, single-center study. The best area under the receiver operating characteristic curve values were detected for aspartate aminotransferase-to-alanine aminotransferase ratio (0.685) for ≥F2, Fibrosis Index (FI; 0.703) for ≥F3; FI (0.872) for ≥F4 and FI (0.864) for cirrhosis. After antiviral treatment, the best area under the receiver operating characteristic curve values were detected in aspartate aminotransferase-to-alanine aminotransferase ratio (0.615) for ≥F2; in FI based on four factors (FIB-4; 0.634) for ≥F3; in FIB-4 (0.678) for ≥F4 and in FIB-4 (0.814) for cirrhosis. FIB-4 and FI showed better performance in defining advanced fibrosis (≥F4) and cirrhosis. Ozdemir demonstrate that the Fibrosis Index based on four factors and the Fibrosis Index showed better performance in defining advanced fibrosis (≥F4) and cirrhosis (≥F5) among noninvasive fibrosis indices including Aspartate Aminotransferase-to-Platelet Ratio Index, Fibrosis Index based on four factors, Aminotransferase-to-Alanine Aminotransferase Ratio and Fibrosis Index.