Beyond bacteria: early-life gut virome link with childhood asthma development

We deeply characterized the early-life gut virome, which consists mainly of bacteriophages (phages) and the diversity of which greatly exceeds bacterial diversity. The virome was associated with later asthma development, independently of the bacterial hosts of the phages; we further uncovered intrig...

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Veröffentlicht in:	Nature medicine 2024, Vol.30 (1), p.43-44
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/1321 692/499 Asthma Bacteria Biomedical and Life Sciences Biomedicine Cancer Research Childhood Children Childrens health Disease prevention Genetics Genomes Hypotheses Immune system Infectious Diseases Metabolic Diseases Molecular Medicine Neurosciences Phages Research Briefing Viruses
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Zusammenfassung:	We deeply characterized the early-life gut virome, which consists mainly of bacteriophages (phages) and the diversity of which greatly exceeds bacterial diversity. The virome was associated with later asthma development, independently of the bacterial hosts of the phages; we further uncovered intriguing interactions with immune genetics.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/s41591-023-02747-0