Enhancing resistance and cell survival in Acipenser ruthenus liver, gill, and kidney cells: The potential of heat shock protein inducers against PAH-benzo[a]pyrene stress
The Caspian Sea has faced many environmental challenges, such as oil pollution. Heat shock proteins (HSPs) play a critical role in stress conditions and physiological changes caused by disease or injury. By evaluating the effects of various HSP inducers (HSPi), including Pro-Tex® (NOP: 800 mM), amyg...
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| creator | Zarei, Sevda Ghafouri, Hossein Vahdatiraad, Leila Heidari, Behrooz Sohrabi, Tooraj |
| description | The Caspian Sea has faced many environmental challenges, such as oil pollution. Heat shock proteins (HSPs) play a critical role in stress conditions and physiological changes caused by disease or injury. By evaluating the effects of various HSP inducers (HSPi), including Pro-Tex® (NOP: 800 mM), amygdalin (AMG: 80 mM), and a novel synthetic compound derived from pirano piranazole (SZ: 80 µm) on isolated cells from Sterlet Sturgeon (
Acipenser ruthenus
) treated with 75% IC
50
PAH-benzo[
a
]pyrene (B
a
P; B75). This study examines whether there is a correlation between exposure to the B
a
P pollutant and HSPs in fish. In vitro, after culturing cells from the liver, kidney, and gills, they were treated with HSPi compounds in the presence and absence of B
a
P. Western blotting was used to assess HSP27, HSP70, and HSP90 expression patterns. A variety of enzyme activities were measured before (without treatment) and after treatment with HSPis and HSPi + B75, including cytochrome P450 (CYP450) activity, specific enzyme activity for acetylcholinesterase (AChE), antioxidant capacity, liver indicator enzymes, cortisol levels, and immunity parameters. When compared to the control group, cells treated with B75 showed the lowest AChE enzyme activity (
p
|
| doi_str_mv | 10.1007/s11356-024-31884-3 |
| format | Article |
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Acipenser ruthenus
) treated with 75% IC
50
PAH-benzo[
a
]pyrene (B
a
P; B75). This study examines whether there is a correlation between exposure to the B
a
P pollutant and HSPs in fish. In vitro, after culturing cells from the liver, kidney, and gills, they were treated with HSPi compounds in the presence and absence of B
a
P. Western blotting was used to assess HSP27, HSP70, and HSP90 expression patterns. A variety of enzyme activities were measured before (without treatment) and after treatment with HSPis and HSPi + B75, including cytochrome P450 (CYP450) activity, specific enzyme activity for acetylcholinesterase (AChE), antioxidant capacity, liver indicator enzymes, cortisol levels, and immunity parameters. When compared to the control group, cells treated with B75 showed the lowest AChE enzyme activity (
p
< 0.0001). CYP450 activity was highest in group B75, while HSPi caused the opposite effect (
p
< 0.0001). HSPi + B75 increased HSP levels and antioxidant parameters while decreasing cortisol and liver indicator enzymes (
p
< 0.0001). HSPi may be a powerful and reliable method for enhancing the resistance of
A. ruthenus
to B
a
P stresses before exposure. Treating cells with HSP-inducing compounds, such as NOP, AMG, and SZ, can assist them in managing stress and increase HSP (27, 70, and 90) protein expression. Furthermore, the study findings suggest that HSPis can also mitigate the adverse effects of stress, ultimately increasing cell survival and resistance.
Graphical Abstract</description><identifier>ISSN: 1614-7499</identifier><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-024-31884-3</identifier><identifier>PMID: 38191735</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acetylcholinesterase ; Acipenser ruthenus ; amygdalin ; antioxidant activity ; Antioxidants ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Benzo(a)pyrene ; Caspian Sea ; Cell survival ; cell viability ; Cortisol ; cytochrome P-450 ; Cytochrome P450 ; Cytochromes P450 ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Enzymatic activity ; Enzyme activity ; Enzymes ; fish ; Gills ; Heat shock proteins ; heat stress ; Hepatocytes ; Hormones ; Hsp27 protein ; Hsp70 protein ; Hsp90 protein ; immunity ; Kidneys ; Liver ; Oil pollution ; oils ; Parameters ; Physiological effects ; pollutants ; pollution ; protein synthesis ; Pyrene ; Research Article ; Survival ; Waste Water Technology ; Water Management ; Water Pollution Control ; Western blotting</subject><ispartof>Environmental science and pollution research international, 2024-02, Vol.31 (6), p.9445-9460</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-12a9fd1a86c1e9aea3fd83f4789501b8883c07b03b40b4e0e7b35914c779fcd23</citedby><cites>FETCH-LOGICAL-c408t-12a9fd1a86c1e9aea3fd83f4789501b8883c07b03b40b4e0e7b35914c779fcd23</cites><orcidid>0000-0003-2245-0697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-024-31884-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-024-31884-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38191735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zarei, Sevda</creatorcontrib><creatorcontrib>Ghafouri, Hossein</creatorcontrib><creatorcontrib>Vahdatiraad, Leila</creatorcontrib><creatorcontrib>Heidari, Behrooz</creatorcontrib><creatorcontrib>Sohrabi, Tooraj</creatorcontrib><title>Enhancing resistance and cell survival in Acipenser ruthenus liver, gill, and kidney cells: The potential of heat shock protein inducers against PAH-benzo[a]pyrene stress</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>The Caspian Sea has faced many environmental challenges, such as oil pollution. Heat shock proteins (HSPs) play a critical role in stress conditions and physiological changes caused by disease or injury. By evaluating the effects of various HSP inducers (HSPi), including Pro-Tex® (NOP: 800 mM), amygdalin (AMG: 80 mM), and a novel synthetic compound derived from pirano piranazole (SZ: 80 µm) on isolated cells from Sterlet Sturgeon (
Acipenser ruthenus
) treated with 75% IC
50
PAH-benzo[
a
]pyrene (B
a
P; B75). This study examines whether there is a correlation between exposure to the B
a
P pollutant and HSPs in fish. In vitro, after culturing cells from the liver, kidney, and gills, they were treated with HSPi compounds in the presence and absence of B
a
P. Western blotting was used to assess HSP27, HSP70, and HSP90 expression patterns. A variety of enzyme activities were measured before (without treatment) and after treatment with HSPis and HSPi + B75, including cytochrome P450 (CYP450) activity, specific enzyme activity for acetylcholinesterase (AChE), antioxidant capacity, liver indicator enzymes, cortisol levels, and immunity parameters. When compared to the control group, cells treated with B75 showed the lowest AChE enzyme activity (
p
< 0.0001). CYP450 activity was highest in group B75, while HSPi caused the opposite effect (
p
< 0.0001). HSPi + B75 increased HSP levels and antioxidant parameters while decreasing cortisol and liver indicator enzymes (
p
< 0.0001). HSPi may be a powerful and reliable method for enhancing the resistance of
A. ruthenus
to B
a
P stresses before exposure. Treating cells with HSP-inducing compounds, such as NOP, AMG, and SZ, can assist them in managing stress and increase HSP (27, 70, and 90) protein expression. Furthermore, the study findings suggest that HSPis can also mitigate the adverse effects of stress, ultimately increasing cell survival and resistance.
Graphical Abstract</description><subject>Acetylcholinesterase</subject><subject>Acipenser ruthenus</subject><subject>amygdalin</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Benzo(a)pyrene</subject><subject>Caspian Sea</subject><subject>Cell survival</subject><subject>cell viability</subject><subject>Cortisol</subject><subject>cytochrome P-450</subject><subject>Cytochrome P450</subject><subject>Cytochromes P450</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Enzymatic activity</subject><subject>Enzyme activity</subject><subject>Enzymes</subject><subject>fish</subject><subject>Gills</subject><subject>Heat shock proteins</subject><subject>heat stress</subject><subject>Hepatocytes</subject><subject>Hormones</subject><subject>Hsp27 protein</subject><subject>Hsp70 protein</subject><subject>Hsp90 protein</subject><subject>immunity</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Oil pollution</subject><subject>oils</subject><subject>Parameters</subject><subject>Physiological effects</subject><subject>pollutants</subject><subject>pollution</subject><subject>protein synthesis</subject><subject>Pyrene</subject><subject>Research Article</subject><subject>Survival</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Western blotting</subject><issn>1614-7499</issn><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhS0EoqXwAiyQJTZdNOCfeGyzG1WFVqoEi7JCKHKcm4nbjBN8k5GGR-Ip8cy0gFjAxj-63zn3Xh1CXnL2hjOm3yLnUi0KJspCcmPy-Ygc8wUvC11a-_iP9xF5hnjLmGBW6KfkSBpuuZbqmPy4iJ2LPsQVTYABp_wB6mJDPfQ9xTltwsb1NES69GGEiJBomqcO4oy0DxtIZ3QV-v5sL7oLTYTtXovv6E0HdBwmiFPIFkNLO3ATxW7wd3RMuZBdQ2xmDwmpW7kQcaKflpdFDfH78MV9HbcJIlCc8mz4nDxpXY_w4v4-IZ_fX9ycXxbXHz9cnS-vC18yMxVcONs23JmF52AdONk2RralNlYxXhtjpGe6ZrIuWV0CA11LZXnptbatb4Q8IacH3zzitxlwqtYBdxu5CMOMleRKLoQU2eh_qLBcKKGk2rm-_gu9HeYU8yKZyrkYxbTMlDhQPg2ICdpqTGHt0rbirNqFXh1Cr3Lo1T70aid6dW8912tofkkeUs6APACYS3EF6Xfvf9j-BOIyuYU</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Zarei, Sevda</creator><creator>Ghafouri, Hossein</creator><creator>Vahdatiraad, Leila</creator><creator>Heidari, Behrooz</creator><creator>Sohrabi, Tooraj</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-2245-0697</orcidid></search><sort><creationdate>20240201</creationdate><title>Enhancing resistance and cell survival in Acipenser ruthenus liver, gill, and kidney cells: The potential of heat shock protein inducers against PAH-benzo[a]pyrene stress</title><author>Zarei, Sevda ; Ghafouri, Hossein ; Vahdatiraad, Leila ; Heidari, Behrooz ; Sohrabi, Tooraj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-12a9fd1a86c1e9aea3fd83f4789501b8883c07b03b40b4e0e7b35914c779fcd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acetylcholinesterase</topic><topic>Acipenser ruthenus</topic><topic>amygdalin</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Benzo(a)pyrene</topic><topic>Caspian Sea</topic><topic>Cell survival</topic><topic>cell viability</topic><topic>Cortisol</topic><topic>cytochrome P-450</topic><topic>Cytochrome P450</topic><topic>Cytochromes P450</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Enzymatic activity</topic><topic>Enzyme activity</topic><topic>Enzymes</topic><topic>fish</topic><topic>Gills</topic><topic>Heat shock proteins</topic><topic>heat stress</topic><topic>Hepatocytes</topic><topic>Hormones</topic><topic>Hsp27 protein</topic><topic>Hsp70 protein</topic><topic>Hsp90 protein</topic><topic>immunity</topic><topic>Kidneys</topic><topic>Liver</topic><topic>Oil pollution</topic><topic>oils</topic><topic>Parameters</topic><topic>Physiological effects</topic><topic>pollutants</topic><topic>pollution</topic><topic>protein synthesis</topic><topic>Pyrene</topic><topic>Research Article</topic><topic>Survival</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zarei, Sevda</creatorcontrib><creatorcontrib>Ghafouri, Hossein</creatorcontrib><creatorcontrib>Vahdatiraad, Leila</creatorcontrib><creatorcontrib>Heidari, Behrooz</creatorcontrib><creatorcontrib>Sohrabi, Tooraj</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zarei, Sevda</au><au>Ghafouri, Hossein</au><au>Vahdatiraad, Leila</au><au>Heidari, Behrooz</au><au>Sohrabi, Tooraj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancing resistance and cell survival in Acipenser ruthenus liver, gill, and kidney cells: The potential of heat shock protein inducers against PAH-benzo[a]pyrene stress</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>31</volume><issue>6</issue><spage>9445</spage><epage>9460</epage><pages>9445-9460</pages><issn>1614-7499</issn><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>The Caspian Sea has faced many environmental challenges, such as oil pollution. Heat shock proteins (HSPs) play a critical role in stress conditions and physiological changes caused by disease or injury. By evaluating the effects of various HSP inducers (HSPi), including Pro-Tex® (NOP: 800 mM), amygdalin (AMG: 80 mM), and a novel synthetic compound derived from pirano piranazole (SZ: 80 µm) on isolated cells from Sterlet Sturgeon (
Acipenser ruthenus
) treated with 75% IC
50
PAH-benzo[
a
]pyrene (B
a
P; B75). This study examines whether there is a correlation between exposure to the B
a
P pollutant and HSPs in fish. In vitro, after culturing cells from the liver, kidney, and gills, they were treated with HSPi compounds in the presence and absence of B
a
P. Western blotting was used to assess HSP27, HSP70, and HSP90 expression patterns. A variety of enzyme activities were measured before (without treatment) and after treatment with HSPis and HSPi + B75, including cytochrome P450 (CYP450) activity, specific enzyme activity for acetylcholinesterase (AChE), antioxidant capacity, liver indicator enzymes, cortisol levels, and immunity parameters. When compared to the control group, cells treated with B75 showed the lowest AChE enzyme activity (
p
< 0.0001). CYP450 activity was highest in group B75, while HSPi caused the opposite effect (
p
< 0.0001). HSPi + B75 increased HSP levels and antioxidant parameters while decreasing cortisol and liver indicator enzymes (
p
< 0.0001). HSPi may be a powerful and reliable method for enhancing the resistance of
A. ruthenus
to B
a
P stresses before exposure. Treating cells with HSP-inducing compounds, such as NOP, AMG, and SZ, can assist them in managing stress and increase HSP (27, 70, and 90) protein expression. Furthermore, the study findings suggest that HSPis can also mitigate the adverse effects of stress, ultimately increasing cell survival and resistance.
Graphical Abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38191735</pmid><doi>10.1007/s11356-024-31884-3</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-2245-0697</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1614-7499 |
| ispartof | Environmental science and pollution research international, 2024-02, Vol.31 (6), p.9445-9460 |
| issn | 1614-7499 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2912525352 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Acetylcholinesterase Acipenser ruthenus amygdalin antioxidant activity Antioxidants Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Benzo(a)pyrene Caspian Sea Cell survival cell viability Cortisol cytochrome P-450 Cytochrome P450 Cytochromes P450 Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Enzymatic activity Enzyme activity Enzymes fish Gills Heat shock proteins heat stress Hepatocytes Hormones Hsp27 protein Hsp70 protein Hsp90 protein immunity Kidneys Liver Oil pollution oils Parameters Physiological effects pollutants pollution protein synthesis Pyrene Research Article Survival Waste Water Technology Water Management Water Pollution Control Western blotting |
| title | Enhancing resistance and cell survival in Acipenser ruthenus liver, gill, and kidney cells: The potential of heat shock protein inducers against PAH-benzo[a]pyrene stress |
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