YB-1: the Jekyll and Hyde of kidney disease?
Y-box–binding protein 1 is a well-described and important regulator of gene transcription, which is linked to various pathologic conditions, including inflammation and fibrosis of the kidney. The identification of a novel and protective crosstalk pathway between podocytes and tubular cells in the ki...
Gespeichert in:
| Veröffentlicht in: | Kidney international 2024-01, Vol.105 (1), p.18-20 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Y-box–binding protein 1 is a well-described and important regulator of gene transcription, which is linked to various pathologic conditions, including inflammation and fibrosis of the kidney. The identification of a novel and protective crosstalk pathway between podocytes and tubular cells in the kidney with Y-box–binding protein 1 acting as a paracrine messenger sheds new light and provides novel opportunities for renoprotection. |
|---|---|
| ISSN: | 0085-2538 1523-1755 1523-1755 |
| DOI: | 10.1016/j.kint.2023.10.020 |