Epigenetic checkpoints regulate the fate and function of CAR-T cells

T cells exist in many functional states, and dynamic transitions from one state to another affect the outcome of adoptive T cell therapy. FOXP1 and KLF2 are now identified as transcriptional regulators of the stemness of CD8 + CAR-T cells and the bifurcation of stem-like CD8 + CAR-T cells into effec...

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Veröffentlicht in:	Nature immunology 2024-01, Vol.25 (1), p.4-6
Hauptverfasser:	Casucci, Monica, Bonini, Chiara, Ruggiero, Eliana
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/2152/1566/1618 631/250/2502 631/67/1059/2325 Biomedical and Life Sciences Biomedicine Cancer CD8 antigen Cell therapy Cells Effector cells Epigenetics Foxp1 protein Genes Immunology Immunotherapy Infectious Diseases Investigations Krueppel-like factor Leukemia Lymphocytes Lymphocytes T Melanoma News & Views news-and-views Transcription factors Tumors
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Beschreibung
Zusammenfassung:	T cells exist in many functional states, and dynamic transitions from one state to another affect the outcome of adoptive T cell therapy. FOXP1 and KLF2 are now identified as transcriptional regulators of the stemness of CD8 + CAR-T cells and the bifurcation of stem-like CD8 + CAR-T cells into effector and exhausted subsets, respectively.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-023-01708-6