First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls
The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO 2 additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved....
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2024-01, Vol.6 (6), p.678-681 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Ishida, Moeka Adachi, Rina Kobayashi, Kazuki Yamamoto, Yukiko Kawahara, Chinatsu Yamada, Tsuyoshi Aoyama, Hiroshi Kanomata, Kyohei Akai, Shuji Lam, Patrick Y. S Sajiki, Hironao Ikawa, Takashi |
| description | The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO
2
additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved.
The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO
2
additive is crucial for the success of the coupling. |
| doi_str_mv | 10.1039/d3cc05447k |
| format | Article |
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2
additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved.
The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO
2
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2
additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved.
The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO
2
additive is crucial for the success of the coupling.</description><subject>Coupling</subject><subject>Enantiomers</subject><subject>Manganese dioxide</subject><subject>Synthesis</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkdFLwzAQxoMobk5ffFcCvohQTZqkbR6lOhWHe1HwrSRp4rq1zUxaYf-9mZsTvJe74_tx3H0HwClG1xgRflMSpRCjNF3sgSEmCY0Yzd731zXjUUooG4Aj7-coBGbZIRiQDCeMUz4E03HlfAdF5-zSel1r1VVfGuYz0UYT0UBl-2VdtR_QWAe7mYZ-1YbkKw-tgXn0AoO60CWUlXCr2h-DAyNqr0-2eQTexvev-WM0mT485beTSBGSdpFAsRaaKIq45DrlojQJEzKLszTRCUexkDg2iJPQloILxiSWmghJEmNCSUbgcjN36exnr31XNJVXuq5Fq23vi5gjniBOszigF__Que1dG7YLFKY44TGigbraUMpZ7502xdJVTbipwKhY21zckTz_sfk5wOfbkb1sdLlDf30NwNkGcF7t1L8_kW-F-4Fg</recordid><startdate>20240116</startdate><enddate>20240116</enddate><creator>Ishida, Moeka</creator><creator>Adachi, Rina</creator><creator>Kobayashi, Kazuki</creator><creator>Yamamoto, Yukiko</creator><creator>Kawahara, Chinatsu</creator><creator>Yamada, Tsuyoshi</creator><creator>Aoyama, Hiroshi</creator><creator>Kanomata, Kyohei</creator><creator>Akai, Shuji</creator><creator>Lam, Patrick Y. S</creator><creator>Sajiki, Hironao</creator><creator>Ikawa, Takashi</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7113-2594</orcidid><orcidid>https://orcid.org/0000-0001-7915-8975</orcidid><orcidid>https://orcid.org/0000-0001-9149-8745</orcidid><orcidid>https://orcid.org/0000-0003-2792-6826</orcidid><orcidid>https://orcid.org/0000-0002-2251-4665</orcidid><orcidid>https://orcid.org/0000-0002-6048-5578</orcidid><orcidid>https://orcid.org/0000-0002-1642-3273</orcidid></search><sort><creationdate>20240116</creationdate><title>First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls</title><author>Ishida, Moeka ; Adachi, Rina ; Kobayashi, Kazuki ; Yamamoto, Yukiko ; Kawahara, Chinatsu ; Yamada, Tsuyoshi ; Aoyama, Hiroshi ; Kanomata, Kyohei ; Akai, Shuji ; Lam, Patrick Y. S ; Sajiki, Hironao ; Ikawa, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-a02eae3c409b9e79adf65ab82876e6902ab12f09376eda9a55b1be3ab36ffb1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Coupling</topic><topic>Enantiomers</topic><topic>Manganese dioxide</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishida, Moeka</creatorcontrib><creatorcontrib>Adachi, Rina</creatorcontrib><creatorcontrib>Kobayashi, Kazuki</creatorcontrib><creatorcontrib>Yamamoto, Yukiko</creatorcontrib><creatorcontrib>Kawahara, Chinatsu</creatorcontrib><creatorcontrib>Yamada, Tsuyoshi</creatorcontrib><creatorcontrib>Aoyama, Hiroshi</creatorcontrib><creatorcontrib>Kanomata, Kyohei</creatorcontrib><creatorcontrib>Akai, Shuji</creatorcontrib><creatorcontrib>Lam, Patrick Y. S</creatorcontrib><creatorcontrib>Sajiki, Hironao</creatorcontrib><creatorcontrib>Ikawa, Takashi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishida, Moeka</au><au>Adachi, Rina</au><au>Kobayashi, Kazuki</au><au>Yamamoto, Yukiko</au><au>Kawahara, Chinatsu</au><au>Yamada, Tsuyoshi</au><au>Aoyama, Hiroshi</au><au>Kanomata, Kyohei</au><au>Akai, Shuji</au><au>Lam, Patrick Y. S</au><au>Sajiki, Hironao</au><au>Ikawa, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2024-01-16</date><risdate>2024</risdate><volume>6</volume><issue>6</issue><spage>678</spage><epage>681</epage><pages>678-681</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO
2
additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved.
The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO
2
additive is crucial for the success of the coupling.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38165949</pmid><doi>10.1039/d3cc05447k</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-7113-2594</orcidid><orcidid>https://orcid.org/0000-0001-7915-8975</orcidid><orcidid>https://orcid.org/0000-0001-9149-8745</orcidid><orcidid>https://orcid.org/0000-0003-2792-6826</orcidid><orcidid>https://orcid.org/0000-0002-2251-4665</orcidid><orcidid>https://orcid.org/0000-0002-6048-5578</orcidid><orcidid>https://orcid.org/0000-0002-1642-3273</orcidid></addata></record> |
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| ispartof | Chemical communications (Cambridge, England), 2024-01, Vol.6 (6), p.678-681 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Coupling Enantiomers Manganese dioxide Synthesis |
| title | First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls |
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