First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls

First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls

The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO 2 additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved....

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2024-01, Vol.6 (6), p.678-681
Hauptverfasser: Ishida, Moeka, Adachi, Rina, Kobayashi, Kazuki, Yamamoto, Yukiko, Kawahara, Chinatsu, Yamada, Tsuyoshi, Aoyama, Hiroshi, Kanomata, Kyohei, Akai, Shuji, Lam, Patrick Y. S, Sajiki, Hironao, Ikawa, Takashi
Format: Artikel
Sprache:eng
Schlagworte:
Coupling
Enantiomers
Manganese dioxide
Synthesis
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Beschreibung
Zusammenfassung:The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO 2 additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved. The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO 2 additive is crucial for the success of the coupling.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05447k